Genomic evolution of polyploid yeast species
Citation:
Jonathan Gordon, 'Genomic evolution of polyploid yeast species', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2008, pp 145Abstract:
In Chapter 2 of this thesis I study how the genome structure and content of yeast has
evolved since a Whole Genome Duplication (WGD) occurred in the lineage approximately
100 million years ago. By using genome data from several extant species whose lineages
arose both before and after the WGD, I parsimoniously reconstructed the genome order and
content for the ancestor that existed immediately prior to the WGD. This ancestor
contained at least 4703 loci, and there are 66 reciprocal translocations, 73 inversions, 5
Robertsonian translocations, 9 single-gene transpositions and 2 multigene transpositions
found between the genome duplicated ancestor and the extant S. cerevisiae genome. Some
of these rearrangements are phylogenetically informative because they are shared by one or
more species to the exclusion of others. The phylogeny inferred by these shared
rearrangements differs from most sequence-based phylogenies. There have been 153 genes
gained in S. cerevisiae since the ancestor, and there are 144 loci in the ancestor that have
been deleted in double copy in S. cerevisiae. Breakpoints created by rearrangements and
the locations of gene gains are enriched for tRNA genes in S. cerevisiae. There is evidence
of breakpoint reuse in rearrangements, and there is an average use of 1.22 rearrangements
per breakpoint.
Author: Gordon, Jonathan
Advisor:
Wolfe, KenQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of GeneticsNote:
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Full text availableKeywords:
Genetics, Ph.D., Ph.D. Trinity College DublinMetadata
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