Browsing Genetics by Title
Now showing items 378-397 of 550
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Paging through history: Parchment as a reservoir of ancient DNA for next generation sequencing
(2015)Parchment represents an invaluable cultural reservoir. Retrieving an additional layer of information from these abundant, dated livestock-skins via the use of ancient DNA (aDNA) sequencing has been mooted by a number of ... -
Panel-Based population next-generation sequencing for inherited retinal degenerations
(2016)Inherited retinopathies affect approximately two and a half million people globally, yet the majority of affected patients lack clear genetic diagnoses given the diverse range of genes and mutations implicated in these ... -
Parallel evolution of the make?accumulate?consume strategy in Saccharomyces and Dekkera yeasts
(Nature, 2011)Saccharomyces yeasts degrade sugars to two-carbon components, in particular ethanol, even in the presence of excess oxygen. This characteristic is called the Crabtree effect and is the background for the 'make?accumulate?consume' ... -
The parallel lives of Joseph Allen Galbraith (1819-90) and Samuel Haughton (1821-97): religion, friendship, scholarship and politics in Victorian Ireland.
(Royal Irish Academy, 2012)Joseph Allen Galbraith and Samuel Haughton were both Junior Fellows at Trinity College Dublin, who in the 1840s became popular lecturers of mathematics-based subjects as well as successful textbook authors. In the 1880s ... -
Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1
(2014)Mitochondrial depolarization promotes Parkin- and PTEN-induced kinase 1 (PINK1)-dependent polyubiquitination of multiple proteins on mitochondrial outer membranes, resulting in the removal of defective mitochondria via ... -
Patterns of gene expression during Arabidopsis flower development from the time of initiation to maturation
(2015)Background The formation of flowers is one of the main model systems to elucidate the molecular mechanisms that control developmental processes in plants. Although several studies have explored gene expression during ... -
Patterns of regulation of gene expression and genetic novelty in mammalian species
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)Genetic novelty is the driving force behind evolution. Consequently, a large amount of genetic research is dedicated to determining the mechanisms behind, and the effects of, the creation of new genes. Where and when these ... -
pBaSysBioII: an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis.
(2010)Plasmid pBaSysBioII was constructed for high-throughput analysis of gene expression in Bacillus subtilis. It is an integrative plasmid with a ligation-independent cloning (LIC) site, allowing the generation of transcriptional ... -
Persistent, ancient constraints shape copy number and expression variation of dosage-sensitive genes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017) -
A perspective on mammalian caspases as positive and negative regulators of inflammation.
(2012)Members of the caspase family of cysteine proteases coordinate the morphological and biochemical events that typify apoptosis. However, neutralization of caspase activity in mammals fails to block death in response to ... -
The phenotypic plasticity of duplicated genes in Saccharomyces cerevisiae and the origin of adaptations
(2017)Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of ... -
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Picking the high hanging fruit : automated ways to annotate awkward genes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)In Chapter 2 I describe the development of software called SearchDOGS (Database of Orthologous Genomic Segments). By identifying regions of conserved local synteny across species using the synteny information contained in ... -
Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products
(2010)Macrophages are involved in many aspects of development, host defense, pathology, and homeostasis. Their normal differentiation, proliferation, and survival are controlled by CSF-1 via the activation of the CSF-1R. A ... -
Plasticity of recurrent inhibition in the Drosophila antennal lobe
(2012)Recurrent inhibition, wherein excitatory principal neurons stimulate inhibitory interneurons that feedback on the same principal cells, occurs ubiquitously in the brain. However, the regulation and function of recurrent ... -
Plxdc2 is a mitogen for neural progenitors
(2011)The development of different brain regions involves the coordinated control of proliferation and cell fate specification along and across the neuraxis. Here, we identify Plxdc2 as a novel regulator of these processes, using ... -
Polycomb group proteins: navigators of lineage pathways led astray in cancer
(2009)The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell ... -
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
(2012)Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional ... -
Population and genomic variation of immune genes in chicken
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Achieving an understanding of the processes shaping diversity at chicken immune genes illuminates their population history, relevance to disease and mechanisms of evolution. Functional variation at genes that determine the ...