Plasticity of recurrent inhibition in the Drosophila antennal lobe
Citation:
Sudhakaran, I.P., Holohan, E.E., Osman, S., Rodrigues, V., Vijay Raghavan, K., Ramaswami, M., Plasticity of recurrent inhibition in the Drosophila antennal lobe, Journal of Neuroscience, 32, 21, 2012, 7225-7231Download Item:
Abstract:
Recurrent inhibition, wherein excitatory principal neurons stimulate inhibitory interneurons that feedback on the same principal cells,
occurs ubiquitously in the brain. However, the regulation and function of recurrent inhibition are poorly understood in terms of the
contributing interneuron subtypes as well as their effect on neural and cognitive outputs. In the
Drosophila
olfactory system, odorants
activate olfactory sensory neurons (OSNs), which stimulate projection neurons (PNs) in the antennal lobe. Both OSNs and PNs activate
localinhibitoryneurons(LNs)thatprovideeitherfeedforwardorrecurrent/feedbackinhibitioninthelobe.Duringolfactoryhabituation,
prior exposure to an odorant selectively decreases the animal’s subsequent response to the odorant. We show here that habituation
occursinresponsetofeedbackfromPNs.OutputfromPNsisnecessaryforolfactoryhabituationand,intheabsenceofodorant,directPN
activation is sufficient to induce the odorant-selective behavioral attenuation characteristic of olfactory habituation. PN-induced habit-
uation occludes further odor-induced habituation and similarly requires GABA
A
Rs and NMDARs in PNs, as well as VGLUT and cAMP
signaling in the multiglomerular inhibitory local interneurons (LN1) type of LN. Thus, PN output is monitored by an LN subtype whose
resultant plasticity underlies behavioral habituation. We propose that recurrent inhibitory motifs common in neural circuits may
similarly underlie habituation to other complex stimuli
Author's Homepage:
http://people.tcd.ie/ramaswamDescription:
PUBLISHED
Author: RAMASWAMI, MANI
Type of material:
Journal ArticleCollections
Series/Report no:
Journal of Neuroscience32
21
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GeneticsDOI:
http://dx.doi.org/10.1242/jcs.113043Metadata
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