Browsing Genetics by Title
Now showing items 178-197 of 552
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A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
(2018)The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 ... -
Family-based molecular genetic studies in bipolar affective disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)This thesis covers gene mapping experiments applied to bipolar affective disorder (BPD), a severe recurrent psychiatric condition with a lifetime prevalence of 1-2%, and a substantial familial component. The study sample ... -
Faster Evolving Primate Genes Are More Likely to Duplicate
(2018)An attractive and long-standing hypothesis regarding the evolution of genes after duplication posits that the duplication event creates new evolutionary possibilities by releasing a copy of the gene from constraint. Apparent ... -
Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma
(2021)Previous studies have shown that glaucomatous Schlemm’s canal endothelial cells (gSCECs) are stiffer and associated with reduced porosity and increased extracellular matrix (ECM) material compared to SCECs from healthy ... -
Fly model causes neurological rethink
(2013)A Drosophila model for a neurological disorder called type 2B Charcot- Marie-Tooth disease reveals that it has its origins in a partial loss of function, rather than a gain of function, which points to the need for ... -
Following the genes: a framework for animal modeling of psychiatric disorders.
(2011)The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models ... -
Fourfold faster rate of genome rearrangement in nematodes than in Drosophila
(2002)We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio ... -
From single nucleotide polymorphisms to high-throughput sequencing in the complex genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive weakening of limb and bulbar muscles resulting in paralysis and death from respiratory failure within three to five years ... -
Function and evolution of genes in the human protein interaction network
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)The research conducted for this thesis aims to elucidate how the human protein interaction network has evolved, and how protein interactions influence the spatial organisation of the metabolic network. The thesis presents ... -
Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)The functional brain is critically dependent on a highly specific and perfectly timed gene-expression programme that underlies neuronal connectivity. Each step of this process, which includes cell migration, axon guidance, ... -
Functional analysis of a novel transmembrane protein, P1xdc2, in the developing nervous system of the chick and mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)Studies utilising the PLAP secretory trap method isolated a gene trap insertion in a novel gene (mouse line KST37) (Leighton et al., 2001) which has since been named Plexin domain containing 2 (Plxdc2). Plxdc2 encodes a ... -
Functional assessment of non-coding regulatory variants in familial breast cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Breast cancer is the most common cancer in Irish women, with almost 3,000 cases diagnosed every year. It often runs in families, and some women inherit a greater risk of developing the disease. Landmark studies on these ... -
Functional characterisation of Arabidopsis genes encoding members of the AP2/ERF transcription factor family
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)The EU Framework 5 REGIA (Regulatory Gene Initiative in Arabidopsis) Consortium, comprising 29 laboratories, was established to investigate transcription factor gene function in Arabidopsis. As part of the REGIA project, ... -
Functional conservation of an ancestral Pellino protein in helminth species
(2015)The immune system of H. sapiens has innate signaling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms such as ... -
Functional Diversification of the Twin-Arginine Translocation Pathway Mediates the Emergence of Novel Ecological Adaptations
(2011)Microorganisms occupy a myriad of ecological niches that show an astonishing diversity. The molecular mechanisms underlying microbes? ecological diversity remain a fundamental conundrum in evolutionary biology. Evidence ... -
Functional Partitioning of Yeast Co-Expression Networks after Genome Duplication
(Public Library of Science, 2006)Several species of yeast, including the baker?s yeast Saccharomyces cerevisiae, underwent a genome duplication roughly 100 million years ago. We analyze genetic networks whose members were involved in this duplication. ... -
Fundus Fluorescein Angiography (FFA) in Human Subjects Displays Circadian Variation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)The relationship between retinal inner blood-retina barrier (iBRB) permeability, the circadian clock and their possible role in retinal pathology is unknown. We performed quantitative fundus fluorescein angiography (FFA) ... -
Further notes on the genealogy and social history of the Carlow family of John Tyndall (1820-1893)
(2013)Using local information and early correspondence we trace aspects of the history of the Carlow family of John Tyndall, concentrating particularly on his sister Emma and several hitherto unknown incidents in her life and ...