Browsing Genetics by Title
Now showing items 82-101 of 553
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Comparative analysis of human and mouse acute phase Serum Amyloid A gene expression
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)The Serum Amyloid A (S AA) proteins are a family of highly conserved lipoproteins secreted by the liver. Their production and release is massively induced under conditions of inflammation or infection by pro-inflammatory ... -
Comparative analysis of poxvirus genome evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)In this thesis I examine the molecular evolution of poxviruses using various comparative genomics approaches. Poxviruses are large DNA viruses that infect vertebrates and insects. Understanding the evolutionary processes ... -
Comparative genomics in yeasts
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)Comparative genomics allows us to delve into the fundamental differences among species that form the basis of biodiversity, as well as the preservative forces of natural selection that have left many things unchanged. It ... -
Comparing Pathways for Retinal and Neuronal Degeneration in Drosophila melanogaster
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Past work to understand the mechanisms of cellular degeneration has either focused on retinal degeneration or neurodegeneration. These studies have revealed that the integrated stress response (ISR) and RNA binding proteins ... -
Comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.
(2015)Aims Women with inherited pathogenic mutations in the BRCA1 or BRCA2 genes have up to an 85% risk of developing breast cancer in their lifetime. However, only about 20% of familial breast cancer is attributed to mutations ... -
Compensatory evolution of gene regulation in response to stress by Escherichia coli lacking RpoS.
(2009)The RpoS sigma factor protein of Escherichia coli RNA polymerase is the master transcriptional regulator of physiological responses to a variety of stresses. This stress response comes at the expense of scavenging for ... -
Complete DNA sequences of the mitochondrial genomes of the pathogenic yeasts Candida orthopsilosis and Candida metapsilosis: Insight into the evolution of linear DNA genomes from mitochondrial telomere mutants.
(Oxford University Press, 2006)We determined complete mitochondrial DNA sequences of the two yeast species, Candida orthopsilosis and Candida metapsilosis, and compared them with the linear mitochondrial genome of their close relative, C.parapsilosis. ... -
A complete mitochondrial genome sequence from a mesolithic wild aurochs (Bos primigenius)
(2010)ackground: The derivation of domestic cattle from the extinct wild aurochs ( Bos primigenius ) has been well-documented by archaeological and genetic studies. Genetic studies point towards the Neolithic Near East as ... -
Complex evolutionary dynamics in simple genomes: the paradoxical survival of intracellular symbiotic bacteria
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)Symbiosis is one of the ways in which nature has been able to generate biological innovation by fusing two organisms with different complexities. Because of these differing complexities, many problems for both organisms ... -
The complex relationship of gene duplication and essentiality.
(2009)In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate ... -
A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs.
(2013)Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et ... -
Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects
(2009)Comparative genomics has become a real tantalizing challenge in the postgenomic era. This fact has been mostly magnified by the plethora of new genomes becoming available in a daily bases. The overwhelming list of new ... -
Concussion and the severity of head impacts in mixed martial arts
(2020)Background: Concern about the consequences of head impacts in US football motivated researchers to investigate and develop instrumentation to measure the severity of these impacts. However, the severity of head impacts ... -
Cone opsin mislocalization in Rpe65-/- mice: A defect that can be corrected by 11-cis retinal
(The Association for Research in Vision and Ophthalmology, Inc., 2005)PURPOSE: In retinal degenerative diseases, rod photoreceptors typically deteriorate more rapidly than cone photoreceptors. In the Rpe65(-/-) mouse, a model for Leber's congenital amaurosis, cones degenerate much more rapidly ... -
Control of conjugation in the plasmid pSf-R27
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)IncHI plasmids are prevalent amongst the Enterobacteriaceae and can confer a multi-drug resistance phenotype upon the host. IncHI plasmids are also thermosensitive for conjugative transfer. Conjugation can occur optimally ... -
Control of floral meristem activity in the model plant Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017)Over the past 30 years, the flower development has been one of the main model to study the genetic control of organogenesis in higher plants. The work on Arabidopsis thaliana has led to the proposal of the ABC model of ... -
Controlled expression and functional characterisation of SasG - a surface protein of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Staphylococcus aureus colonises the moist squamous epithelium of the anterior nares. One of the adhesins likely to be responsible is the S. aureus surface protein G (SasG) which has sequence similarity with the proteins ... -
Correspondence of Charles Darwin on James Torbitt's project to breed blight-resistant potatoes
(Edinburgh University Press, 2008)The most prolific of Darwin?s correspondents from Ireland was James Torbitt, an enterprising grocer and wine merchant of 58 North Street, Belfast. Between February 1876 and March 1882, 141 letters were exchanged on the ...