The complex relationship of gene duplication and essentiality.
Citation:
Makino, T, Hokamp, K, McLysaght, A, The complex relationship of gene duplication and essentiality., Trends in genetics, 25, 4, 2009, 152 - 155Download Item:
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Abstract:
In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.
Author's Homepage:
http://people.tcd.ie/mclysagahttp://people.tcd.ie/kahokamp
Description:
PUBLISHED
Author: Mc Lysaght, Aoife; Hokamp, Karsten
Type of material:
Journal ArticleCollections:
Series/Report no:
Trends in genetics25
4
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Full text availableKeywords:
Genetics, singleton geneSubject (TCD):
Genes & SocietyDOI:
http://dx.doi.org/10.1016/j.tig.2009.03.001ISSN:
0168-9525Licences: