The complex relationship of gene duplication and essentiality.
Citation:Makino, T, Hokamp, K, McLysaght, A, The complex relationship of gene duplication and essentiality., Trends in genetics, 25, 4, 2009, 152 - 155
The complex relationship 1.pdf (Published (author's copy) - Peer Reviewed) 112.2Kb
The complex relationship 2.pdf (Published (author's copy) - Peer Reviewed) 36.81Kb
In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.
Type of material:Journal Article
Series/Report no:Trends in genetics
Availability:Full text available
Subject (TCD):Genes & Society