Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects
Citation:
Commins, J., Toft, C., Fares, M.A., Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects, Biological Procedures Online, 11, 2009, 52-78Download Item:
1-s2.0-S016895251300084X-main.pdf (Published (publisher's copy) - Peer Reviewed) 1.466Mb
Abstract:
Comparative genomics has become a real tantalizing challenge in the postgenomic era. This fact has been
mostly magnified by the plethora of new genomes becoming available in a daily bases. The overwhelming
list of new genomes to compare has pushed the field of bioinformatics and computational biology forward
toward the design and development of methods capable of identifying patterns in a sea of swamping data
noise. Despite many advances made in such endeavor, the ever-lasting annoying exceptions to the general
patterns remain to pose difficulties in generalizing methods for comparative genomics. In this review, we
discuss the different tools devised to undertake the challenge of comparative genomics and some of the
exceptions that compromise the generality of s
uch methods. We focus on endosymbiotic bacteria of
insects because of their genomic dynamics peculiarities when compared to free-living organisms
Author's Homepage:
http://people.tcd.ie/faresmDescription:
PUBLISHED
Author: FARES, MARIO ALI
Type of material:
Journal ArticleCollections:
Series/Report no:
Biological Procedures Online;11;
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