Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease
Citation:Róisín M. McManus, 'Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015, pp 340
McManus TCD THESIS 10624 Role of.pdf (PDF) 187.7Mb
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, however, it has not been established if these are a consequence of ongoing neurodegeneration or whether inflammation itself contributes to disease pathogenesis. T cells have been reported in the AD brain and clinical trials involving immunization with Aβ induced increased T cell infiltration into the brain and meningoencephalitis in some patients. In this study, the effect of Aβ-specific T cells was assessed in vitro and in vivo.
Author: McManus, Róisín M.
Publisher:Trinity College (Dublin, Ireland). School of Biochemistry and Immunology
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Type of material:thesis
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