The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes
Citation:Chris M. Egan, 'The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2012, pp 187
Egan TCD THESIS 10452 The Chromodomain.pdf (PDF) 106.2Mb
The candidate tumour suppressor gene chromodomain, helicase DNA-binding protein 5 (CHD5) is frequently deleted in neuroblastoma. However, little is known about the role of the CHD5 protein during normal development or its mechanism of action. The work presented here reveals that CHD5 is a neuronal specific chromatin remodeller protein. Furthermore, knockdown of the CHD5 protein in both in vitro and in vivo models leads to a block of neuronal differentiation and an accumulation of undifferentiated neuronal progenitor like cells.
Author: Egan, Chris M.
Publisher:Trinity College (Dublin, Ireland). Department of Genetics
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Type of material:thesis
Availability:Full text available