Immune regulation by interferon-beta in multiple sclerosis
Citation:
Cheryl Sweeney, 'Immune regulation by interferon-beta in multiple sclerosis', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010, pp 284Download Item:
Abstract:
Interferon (IFN)-β is a commonly used therapy for patients with relapsing remitting multiple sclerosis (RRMS). Although IFN-β has been shown to exert various immunomodulatory effects, the therapeutic mechanisms are still poorly understood. Furthermore, a high percentage of patients fail to respond to therapy and while in some cases treatment failure can be attributed to the development of neutralising antibodies (NAB) to IFN-β, there is still no valid explanation as to why a large subgroup of patients fail to respond to IFN-β.
Author: Sweeney, Cheryl
Advisor:
Fletcher, JeanQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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Full text availableKeywords:
Biochemistry, Ph.D., Ph.D. Trinity College DublinMetadata
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