Bioenergetics and mitochondrial dynamics in cancer cells and neurons
Citation:
Stephen Quinn, 'Bioenergetics and mitochondrial dynamics in cancer cells and neurons', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012, pp 282Download Item:
Abstract:
Mitochondria in mammalian cells exist as a highly dynamic and interconnected reticulum. This reticular ultrastructure is defined by the opposing forces of fission and fusion, mainly mediated by a group of large GTPases collectively known as mitodynamins. The regulation of fission and fusion is poorly understood but it is thought that bioenergetics and dynamics engage in a bi-directional crosstalk, such that disturbing one will have deleterious effects on the other. The pathophysiological hallmarks of mitochondrial dysfunction are evident both in cancer and neurodegeneration, implicating a role for disturbed mitochondrial dynamics. This study explores the effects of bioenergetic modulation on mitochondrial fusion rates in human cervical carcinoma HeLa cells and rat primary cortical neurons.
Author: Quinn, Stephen
Advisor:
Davey, GavinQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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Full text availableKeywords:
Biochemistry, Ph.D., Ph.D. Trinity College DublinMetadata
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