An investigation of the safety, efficacy, and possible mechanisms of action, of the antihypertensive nilvadipine, in patients with mild moderate Alzheimer's disease
Citation:
Sean Kennelly, 'An investigation of the safety, efficacy, and possible mechanisms of action, of the antihypertensive nilvadipine, in patients with mild moderate Alzheimer's disease', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2011, pp 194Download Item:
Abstract:
This doctoral investigation endeavoured to explore how patients with Alzheimer's disease (AD) would respond to treatment with the antihypertensive nilvadipine. Initially I reviewed the complex relationship between blood pressure (BP) and the incidence of AD. Mid-life hypertension appears to be a strong and consistent risk factor for AD, whereas it is less clear how high BP in later life influences ones risk. Importantly it also appears that low BP; especially later in life is also associated with an increased risk of developing AD. Patients, who develop AD, also appear to have a reduction in their BP preceding the onset of clinical symptoms. I discuss how the risk for AD attributable to different BP's may be as result of diminished cerebral perfusion.
Author: Kennelly, Sean
Advisor:
Kenny, RoseQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical GerontologyNote:
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