Browsing Medical Gerontology (Theses and Dissertations) by Date of Publication
Now showing items 1-20 of 29
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The effect of acute traumatic brain injury on cardiovascular homeostasis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2008)Acute traumatic brain injury (TBI) remains the most common cause of death from multiple trauma. The cardiovascular homeostatic responses to haemorrhage and injury are co-coordinated in the central nervous system. Coincidental ... -
Adaptation to stroke and a model of successful ageing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2008)The focus of this research is to apply and examine the Baltes’ successful ageing model of selection, optimization and compensation (SOC) (Baltes & Baltes, 1990) in the context of stroke which has sudden onset and uncertain ... -
Analysis and biophysical modelling of baroreflex stimulation with applications in syncope and falls : a neural engineering approach
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2011)Carotid Sinus Hypersensitivity (CSH) is an age related disorder, and a common cause of recurrent falls and syncope in the elderly. CSH is prevalent in patients with Dementia and Parkinson's disease and is a strong predictor ... -
An investigation of the safety, efficacy, and possible mechanisms of action, of the antihypertensive nilvadipine, in patients with mild moderate Alzheimer's disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2011)This doctoral investigation endeavoured to explore how patients with Alzheimer's disease (AD) would respond to treatment with the antihypertensive nilvadipine. Initially I reviewed the complex relationship between blood ... -
Investigation of apraxia of speech and linguistic dysprosody following acute ischaemic hemispheral stroke
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2011)Apraxia of speech (AOS) is a disorder of motor speech programming. Affected patients typically have hesitant, groping speech with impaired prosody. Automatic speech is relatively well preserved compared to propositional ... -
Autonomic influences on cognitive impairment : determinants of conversion to dementia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2012)Neuropathological, neurochemical and multimodal neuroimaging studies suggest that components of the central autonomic network are affected by the neurodegenerative changes of Alzheimer’s pathology in Mild Cognitive Impairment ... -
An investigation of the incidence of falling and risk factors for falls in adults with advanced cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2012)The principal aims of this doctoral investigation were to identify the incidence of falls and risk factors for falling in adults with advanced cancer. -
Autonomic function and depression in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2013)The principle aims of this doctoral investigation were to provide new insights into the relationship between depression and cardiovascular disease (CVD) by investigating the functioning of the autonomic nervous system (ANS) ... -
Multiple medication use in the middle and older age population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2013)Polypharmacy in the older population is increasingly common and can represent necessary preventative therapies or potential inappropriate prescribing and be a risk factor for falls. In addition, medications with anti-cholinergic ... -
Vasovagal Syncope in the older adult
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2013)Vasovagal Syncope (VVS) is a common form of neurally mediated syncope which affects at least one third of the population at least once in their lifetime. Commonly referred to as a “simple faint” and often described as ... -
Aesthetic deprivation : the role of aesthetics for older patients in hospital
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)While arts have been integral to all cultures, it is a relatively recent research phenomenon to explore and examine the association between arts and health and well-being (Johnson and Stanley, 2007). This research centres ... -
Fear of falling in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)The principle aim of this doctoral investigation was to provide new insights into the prevalence, risk factors and negative associations of fear of falling (FOF) by examining these factors in a population sample of older adults. -
Haemodynamic stroke and transient ischaemic attack secondary to neurocardiovascular instability
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)Introduction: Presyncope or syncope are regarded as benign conditions. In patients with severe large artery disease, hypotension may potentiate infarction, specifically in low-flow vulnerable, borderzone regions of the ... -
Autonomic influences on cognitive performance at a population level
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)The principle aims of this doctoral investigation were to provide new insights into the relationship between cardiovascular disease (CVD) and cognitive performance, by investigating the function of the autonomic nervous ... -
The influence of perceptions of ageing on frailty and cognitive function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2015)The aim of this thesis is to investigate whether perceptions of ageing influence cognition and frailty in later life. Although much experimental work has shown that priming older adults with negative stereotypes about ... -
Treatment of osteoporosis with recombinant parathyroid hormone, its effects on bone, total body muscle and fat composition and factors determining response to this therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2015)Total body bone mineral density (BMD) is relatively underutilised as an assessment tool for osteoporosis. Studies to date on Body composition have not clearly identified key factors which contribute to total body BMD, ... -
Cardiovascular associations of falls and syncope in the elderly
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2017)The principle aims of this doctoral investigation are to provide new insights into the relationship between cardiovascular disease (CVD) and falls in the elderly population in Ireland. The rapidly ageing global demographic ... -
Impact of assistance on the quality of life of older adults with activities of daily living & instrumental activities of daily living disabilities
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2018)As populations age, incidence of functional limitation including disability in Activities of Daily Living and Instrumental Activities of Daily Living increases. This creates a higher level of demand for technological and ... -
Cardiovascular Autonomic Nervous System, Blood Pressure Instability and Brain Health in Older Adults: Population-Based Perspectives
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)The aim of this thesis is to provide new insights into the shared pathways by which the cardiovascular autonomic nervous system underpins optimal regulation of affect and cognitive function in older adults. Ageing is ... -
The Effects of Acute and Chronic Exercise on Brain Derived Neurotrophic Factor and Cognitive Performance in Mild Cognitive Impairment
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)Introduction: Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that supports neural survival, growth and synaptic plasticity and is upregulated through exercise. While the exact neuronal mechanisms underlying the ...