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dc.contributor.advisorKenny, Rose
dc.contributor.authorKennelly, Sean
dc.date.accessioned2017-01-19T15:38:13Z
dc.date.available2017-01-19T15:38:13Z
dc.date.issued2011
dc.identifier.citationSean Kennelly, 'An investigation of the safety, efficacy, and possible mechanisms of action, of the antihypertensive nilvadipine, in patients with mild moderate Alzheimer's disease', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2011, pp 194
dc.identifier.otherTHESIS 9162
dc.identifier.urihttp://hdl.handle.net/2262/79075
dc.description.abstractThis doctoral investigation endeavoured to explore how patients with Alzheimer's disease (AD) would respond to treatment with the antihypertensive nilvadipine. Initially I reviewed the complex relationship between blood pressure (BP) and the incidence of AD. Mid-life hypertension appears to be a strong and consistent risk factor for AD, whereas it is less clear how high BP in later life influences ones risk. Importantly it also appears that low BP; especially later in life is also associated with an increased risk of developing AD. Patients, who develop AD, also appear to have a reduction in their BP preceding the onset of clinical symptoms. I discuss how the risk for AD attributable to different BP's may be as result of diminished cerebral perfusion.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14633285
dc.subjectMedical Gerontology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleAn investigation of the safety, efficacy, and possible mechanisms of action, of the antihypertensive nilvadipine, in patients with mild moderate Alzheimer's disease
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 194
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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