Browsing Medical Gerontology (Theses and Dissertations) by Title
Now showing items 1-20 of 29
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Adaptation to stroke and a model of successful ageing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2008)The focus of this research is to apply and examine the Baltes’ successful ageing model of selection, optimization and compensation (SOC) (Baltes & Baltes, 1990) in the context of stroke which has sudden onset and uncertain ... -
Aesthetic deprivation : the role of aesthetics for older patients in hospital
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)While arts have been integral to all cultures, it is a relatively recent research phenomenon to explore and examine the association between arts and health and well-being (Johnson and Stanley, 2007). This research centres ... -
The Age-Old Question of ANCA-Associated Vasculitis
(Trinity College Dublin. School of Medicine. Medical Gerontology, 2023)Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis (AAV) is a group of systemic autoimmune disorders characterised by severe inflammation of the small blood vessels. Unusually for an autoimmune disease, ... -
Ageing outcomes in women and men in Ireland: the role of the religious social context
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2020)Aim & background: The aim of this thesis is to explore how the religious social context in Ireland has helped shape the health and ageing outcomes of older women and men. Understanding the factors behind the ability to ... -
An investigation of the incidence of falling and risk factors for falls in adults with advanced cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2012)The principal aims of this doctoral investigation were to identify the incidence of falls and risk factors for falling in adults with advanced cancer. -
An investigation of the safety, efficacy, and possible mechanisms of action, of the antihypertensive nilvadipine, in patients with mild moderate Alzheimer's disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2011)This doctoral investigation endeavoured to explore how patients with Alzheimer's disease (AD) would respond to treatment with the antihypertensive nilvadipine. Initially I reviewed the complex relationship between blood ... -
Analysis and biophysical modelling of baroreflex stimulation with applications in syncope and falls : a neural engineering approach
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2011)Carotid Sinus Hypersensitivity (CSH) is an age related disorder, and a common cause of recurrent falls and syncope in the elderly. CSH is prevalent in patients with Dementia and Parkinson's disease and is a strong predictor ... -
The Association between Blood Pressure, Cerebral Perfusion and Late Life Depression
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2020)Background: While late life is generally characterised by contentment and happiness, depression in later life confers an independently increased risk of early mortality, cognitive and functional decline and nursing home ... -
Autonomic function and depression in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2013)The principle aims of this doctoral investigation were to provide new insights into the relationship between depression and cardiovascular disease (CVD) by investigating the functioning of the autonomic nervous system (ANS) ... -
Autonomic influences on cognitive impairment : determinants of conversion to dementia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2012)Neuropathological, neurochemical and multimodal neuroimaging studies suggest that components of the central autonomic network are affected by the neurodegenerative changes of Alzheimer’s pathology in Mild Cognitive Impairment ... -
Autonomic influences on cognitive performance at a population level
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)The principle aims of this doctoral investigation were to provide new insights into the relationship between cardiovascular disease (CVD) and cognitive performance, by investigating the function of the autonomic nervous ... -
Cardiovascular associations of falls and syncope in the elderly
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2017)The principle aims of this doctoral investigation are to provide new insights into the relationship between cardiovascular disease (CVD) and falls in the elderly population in Ireland. The rapidly ageing global demographic ... -
Cardiovascular Autonomic Nervous System, Blood Pressure Instability and Brain Health in Older Adults: Population-Based Perspectives
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)The aim of this thesis is to provide new insights into the shared pathways by which the cardiovascular autonomic nervous system underpins optimal regulation of affect and cognitive function in older adults. Ageing is ... -
Clinical Decision Support for the Assessment of Syncope and Falls: Novel Applications of Cerebral Perfusion Measurement and Big Data Analytics
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2023)Syncope, defined as a transient loss of consciousness due to cerebral hypoperfusion, is common in both young and old, with syncope an attributable cause of unexplained falls (UF) in older adults. Both syncope and falls ... -
Determinants of Physical Activity Engagement and Physical Activity Intervention Adherence in Individuals with Mild Cognitive Impairment: A Mixed Methods Study
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2022)The overarching aim of this thesis was to to identify the determinants of PA engagement and PA intervention adherence in individuals with MCI to expand on this under-researched topic and better inform PA promotion and ... -
The Effects of Acute and Chronic Exercise on Brain Derived Neurotrophic Factor and Cognitive Performance in Mild Cognitive Impairment
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)Introduction: Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that supports neural survival, growth and synaptic plasticity and is upregulated through exercise. While the exact neuronal mechanisms underlying the ... -
An evaluation ofthe Allostatic Load framework for quantifying differences inhealth and longevity
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2023)The Allostatic Load (AL) framework posits that chronic or repeated exposure to stressors can cause dysregulation of multiple interrelated physiological systems, which if prolonged, may ultimately lead to deteriorations in ... -
Exploring Novel Biomarkers of Brain Health in Midlife Type 2 Diabetes Mellitus (ENBIND)
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2020)Type 2 Diabetes Mellitus (T2DM) in midlife (between the ages of 35-65) is associated with a two-fold increased risk of dementia in later life. Despite this, knowledge around the pathophysiological mechanisms linking T2DM ... -
Fear of falling in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)The principle aim of this doctoral investigation was to provide new insights into the prevalence, risk factors and negative associations of fear of falling (FOF) by examining these factors in a population sample of older adults. -
Haemodynamic stroke and transient ischaemic attack secondary to neurocardiovascular instability
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)Introduction: Presyncope or syncope are regarded as benign conditions. In patients with severe large artery disease, hypotension may potentiate infarction, specifically in low-flow vulnerable, borderzone regions of the ...