Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 401-420 of 626
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Nanotechnology in pulmonary medicine
(2020)Nanotechnology in medicine-nanomedicine-is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to ... -
Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids
(InTech, 2018)The poor clinical translation of oncological nanomedicine products is one of the greatest challenges faced by research today. The use of reductionist in vitro models of human cancer and non-predictive animal models is ... -
Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis
(2018)Objectives: Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a debilitating terminal condition. Informal caregivers are key figures in ALS care provision. The physical, psychological and ... -
Neonatal adiposity increases the risk of atopic dermatitis during the first year of life.
(2016)BACKGROUND: Early nutrition and adiposity have been linked to atopic dermatitis (AD) development. OBJECTIVE: We sought to describe risk factors for AD in the first year of life in infants participating in the Cork ... -
Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis.
(2012)Background: Depletion of T cells following infection by Mycobacterium tuberculosis (Mtb) impairs disease resolution, and interferes with clinical test performance that relies on cell-mediated immunity. A number of mechanisms ... -
Neurophysiological markers of network dysfunction in neurodegenerative diseases
(Elsevier, 2019)There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, ... -
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice.
(2013)Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key ... -
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
(2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ... -
New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid.
(2014)We have prepared a new panel of 23 BA derivatives of DCA, chenodeoxycholic acid (CDCA) and lithocholic acid (LCA) in order to study the effect of dual substitution with 3-azido and 24- amidation, features individually ... -
NF-κB regulation: The nuclear response
(2009)Nuclear factor ?B (NF-?B) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-?B is involved in a wide range of biological ... -
Nivolumab plus ipilimumab in non-small-cell lung cancer
(2019)Nivolumab and ipilimumab, two therapeutic immune checkpoint inhibitor antibodies that block PD-1and CTLA-4, respectively, have indications in cancer as single agents and in combination. In this Review, we examine the ... -
NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient
(2017)Childhood obesity is a major global concern, with over 50 million children now classified as obese. Obesity has been linked to the development of numerous chronic inflammatory diseases, including type 2 diabetes and multiple ... -
No effect of an oleoylethanolamide-related phospholipid on satiety and energy intake: a randomised controlled trial of phosphatidylethanolamine
(BioMed Central, 2008)Phosphatidylethanolamine (PE) is a phospholipid which is biosynthesized into long chain N-acylethanolamines (NAEs) including oleoylethanolamide (OEA), a known inhibitor of food intake. The aim of this study was to investigate ... -
Nomenclature and Definition of Atrophic Lesions in Small Bowel Capsule Endoscopy: An International Delphi Consensus Statement of the International CApsule Endoscopy REsearch (I-CARE) Group.
(2022)Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; (2) Methods: The Delphi technique ... -
Non-invasive molecular tests for H. pylori
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Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
(2012)Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch ... -
Nucleophosmin: From structure and function to disease development
(2016)Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement ...
