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Clinical Medicine (Theses and Dissertations)
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Thrombin generation parameters, relationship with cerebral micro-embolic signal status, and a systematic review of the literature on platelet biomarkers in patients with symptomatic and asymptomatic carotid stenosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background:?Activation of platelets and the coagulation system are integrally involved in acute thrombus formation and distal thrombo-embolism. A better understanding of these complex thrombotic and haemostatic pathways ... -
Adaptive and Innate TH1 and TH17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Introduction: Sepsis carries a significant burden to health care. Almost a third of ICU patients have sepsis on admission or develop it during their admission. Sepsis carries a high mortality and affects all age groups ... -
Heart Rate Recovery Velocity in Cardiac Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Introduction Rate of recovery of heart rate between 10 and 20 seconds following orthostatic challenge (HRR10-20) is a risk factor for all-cause mortality. Furthermore, both cardiac rehabilitation and completeness of coronary ... -
Hungry for More: Measuring Metabolomic Responses in ANCA-Activated Monocytes
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Immunometabolism examines the links between immune cell function and their metabolism. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have uncovered unique insights into cellular metabolomics. ... -
Neuropsychological and Neuropsychiatric Endophenotypes in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive muscle weakness and death, usually within 3-5 years from symptom onset. ALS is now recognized to be a multi-system ...
