RSS 1.0Clinical Medicine (Scholarly Publications)
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Enrichment of circulating head and neck tumour cells using spiral microfluidic technology
(2017)Whilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this is that the rate of distant metastasis has ... -
Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
(2016)Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and ... -
A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution
(2016)Single-stranded DNA binding proteins (SSBs) play an important role in DNA processing events such as replication, recombination and re- pair. Human single-stranded DNA binding pro- tein ... -
Nucleophosmin: From structure and function to disease development
(2016)Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement ... -
HSSB1 (NABP2/OBFC2B) is regulated by oxidative stress
(2016)The maintenance of genome stability is an essential cellular process to prevent the development of diseases including cancer. hSSB1 (NABP2/ OBFC2A) is a critical component of the DNA damage response where it participates ...
