Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 429-448 of 638
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Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children
(Oxford University Press, 2016)Background: Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]). ... -
Old King Coal - molecular mechanisms underlying an ancient treatment for atopic eczema.
(2013)Traditional remedies for common disorders have been known for centuries, but insight into their mechanism of action is often limited. In this issue of the JCI, Joost Schalkwijk’s research group at the Radboud University ... -
Optimally tolerated dose of lapatinib in combinationwith docetaxel plus trastuzumab in first-line treatmentof HER2-positive metastatic breast cancer
(2013)Background: This phase IB, open-label, dose-escalation study evaluated the safety, tolerability, and optimally tolerated regimen (OTR) of lapatinib in combination with docetaxel and trastuzumab in patients with ... -
Oral levosimendan in amyotrophic lateral sclerosis: A phase II multicentre, randomised, double-blind, placebo-controlled trial
(2019)Objective: To evaluate the efficacy and safety of oral levosimendan in patients with amyotrophic lateral sclerosis (ALS). This phase II, randomised, double-blind, placebo-controlled, crossover, three-period study with 6 ... -
Oral symptom assessment tools in patients with advanced cancer: a scoping review
(2022)Purpose: Oral symptoms are common in patients with advanced cancer. The aim of this scoping review was to identify oral symptom assessment tools that have been specifically utilised in patients with "advanced cancer". Methods: ... -
Overweight and obesity among older adults upon admission to hospital
(2011)Poor nutritional status, which includes both under- and over-nutrition, is associated with poor health outcomes. This cross-sectional study assessed the nutritional status of older patients admitted to an acute geriatric ... -
Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives
(BMJ, 2011)Background: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition. Optimal management requires a palliative approach from diagnosis with emphasis on patient autonomy, dignity and ... -
Palliative care in the era of novel oncological interventions: needs some "tweaking"
(2022)Cancer treatment has evolved enormously over the last 20 years, with developments in surgery, radiotherapy, chemo- therapy, targeted therapy, and immunotherapy. As a result, many cancer patients have improved outcomes ... -
Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.
(2013)Trichinella spiralis is a highly destructive parasitic nematode that invades and destroys intestinal epithelial cells, injures many different tissues during its migratory phase, and occupies and transforms myotubes during ... -
The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: A population- based study of consultations, interventions and costs.
(2017)Background: Amyotrophic Lateral Sclerosis (ALS) is a devastating neurological condition that requires coordinated, multidisciplinary clinical management. ALS is prone to misdiagnosis as its signs and symptoms may be ... -
Patient journey to a specialist amyotrophic lateral sclerosis multidisciplinary clinic: an exploratory study.
(2015)BACKGROUND: The multidisciplinary approach in the management of Amyotrophic Lateral Sclerosis (ALS) has been shown to provide superior care to devolved care, with better survival, improved quality of care, and quality ... -
Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes.
(2016)The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), plays an important immunomodulatory role, regulating transcription of genes in the innate and adaptive immune system. The present study examines patterns of ... -
Pauci Immune crescentic glomerulonephritis in a patient with T-cell lymphoma and argyria
(2016)Background: Silver is a transition metal, toxic when ingested in significant amounts, causing argyria (skin deposition) and argyrosis (eye deposition). It is excreted mainly via the gastrointestinal tract with only small ... -
Pellino3 ubiquitinates RIP2 and mediates NOD2-induced signaling and protective effects in colitis
(2013)Mutations that result in loss of function of Nod2, an intracellular receptor for bacterial peptidoglycan, are associated with Crohn's disease. Here we found that the E3 ubiquitin ligase Pellino3 was an important mediator ... -
Performance measures for small-bowel endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.
(2019)The European Society of Gastrointestinal Endoscopy (ESGE) together with the United European Gastroenterology (UEG) recently developed a short list of performance measures for small-bowel endoscopy (i.e. small-bowel capsule ...