Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 204-223 of 626
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Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo.
(2014)OBJECTIVE: Bile acids are important regulators of intestinal physiology, and the nuclear bile acid receptor, farnesoid X receptor (FXR), is emerging as a promising therapeutic target for several intestinal disorders. ... -
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity
(2019)The prevalence of obesity is rising worldwide, and obese patients constitute a specific population in the intensive care unit. Acute respiratory distress syndrome (ARDS) incidence is increased in obese patients. Exposure ... -
Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis.
(2015)Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk factor for atopic dermatitis (AD) and are known to cause an epidermal barrier defect. The nature of this barrier defect is not fully ... -
Filaggrin in the frontline: role in skin barrier function and disease.
(Company of Biologists, 2009)Recently, loss-of-function mutations in FLG, the human gene encoding profilaggrin and filaggrin, have been identified as the cause of the common skin condition ichthyosis vulgaris (which is characterised by dry, scaly ... -
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.
(2012)Background Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH. Because higher pH activates SC protease activity, we hypothesized ... -
Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis.
(2014)Background Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin is a multifunctional protein and plays a key role in skin barrier ... -
First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru
(2014)BACKGROUND: In endemic settings, Helicobacter pylori infection can occur shortly after birth and may be associated with a reduction in childhood growth. MATERIALS AND METHODS: This study investigated what factors ... -
First-line nivolumab plus ipilimumab in advanced non-small-cell lung cancer (CheckMate 568): Outcomes by programmed death ligand 1 and tumor mutational burden as biomarkers
(2019)PURPOSE: CheckMate 568 is an open-label phase II trial that evaluated the efficacy and safety of nivolumab plus low-dose ipilimumab as first-line treatment of advanced/metastatic non–small-cell lung cancer (NSCLC). We ... -
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment
(2010)We studied the function of plasma membrane microdomains defined by the proteins flotillin 1 and flotillin 2 in uropod formation and neutrophil chemotaxis. Flotillins become concentrated in the uropod of neutrophils after ... -
Folate and vitamin B12 in idiopathic male infertility.
(2011)Although methylenetetrahydrofolate reductase, a folate enzyme gene, has been associated with idiopathic male infertility, few studies have examined other folate-related metabolites and genes. We investigated whether ... -
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.
(2008)BACKGROUND Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folate-related genes associated ... -
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.
(John Wiley, 2008)BACKGROUND?Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folaterelated genes associated with ... -
Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum
(2007)Background All flour in the USA is fortified with folic acid at a level of 140 ?g/100 g which is estimated to supply an extra 100 ?g daily to the average diet. Some researchers have advocated that this be increased to ... -
Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration.
(2012)Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. Am J Physiol Endocrinol Metab 301: E000-E000, 2011. First published September 20, 2011; 10.1152/ajpendo. ... -
From first symptoms to diagnosis of amyotrophic lateral sclerosis: Perspectives of an Irish informal caregiver cohort - A thematic analysis
(2017)Objectives: Informal caregivers play an integral part in the management of amyotrophic lateral sclerosis (ALS). The objective of this study was to explore the journey from first problem symptoms to diagnosis from the ... -
The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders
(2016)Background: The Frontal Assessment Battery (FAB) is a short battery designed to assess frontal executive functioning, but data for interpretation of performance are limited. Objectives: The Trinity, Ulster, Department ... -
Functional connectivity changes in resting-state EEG as potential biomarker for Amyotrophic Lateral Sclerosis
(2015)Background Amyotrophic Lateral Sclerosis (ALS) is heterogeneous and overlaps with frontotemporal dementia. Spectral EEG can predict damage in structural and functional networks in frontotemporal dementia but has never ...
