Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 489-508 of 638
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Quantum dots in nanomedicine: Recent trends, advances and unresolved issues
(2015)The review addresses the current state of progress in the use of ultra-small nanoparticles from the category of quantum dots (QDs), which presently embraces a widening range of nanomaterials of different nature, including ... -
r2VIM: A new variable selection method for random forests in genome-wide association studies
(2016)Background Machine learning methods and in particular random forests (RFs) are a promising alternative to standard single SNP analyses in genome-wide association studies (GWAS). RFs provide variable importance measures ... -
RACK1 to the future – a historical perspective.
(2013)This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1 ’ s role in the immune system, the heart and the brain were discussed and ... -
RAD51 135G>C modifies breast cancer risk among BRCA2 mutation carriers: Results from a combined analysis of 19 studies
(The American Society of Human Genetics, 2007)Though much progress has been made in understanding the role of two major high-risk breast cancer (BC) susceptibility genes, BRCA1 and BRCA2, it remains unclear what causes the observed variation in risk between mutation ... -
RanGTPase: A Candidate for Myc-Mediated Cancer Progression
(2013)BACKGROUND: Ras-related nuclear protein (Ran) is required for cancer cell survival in vitro and human cancer progression, but the molecular mechanisms are largely unknown. METHODS: We investigated the effect of the ... -
The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation
(American Society for Nutrition, 2006)Background: Evidence is conflicting as to whether the bioavailability of food folates is influenced by the extent of their conjugation. Objective: The objective was to compare the bioavailability of 3 representative ... -
Receptor tyrosine kinases and their activation in melanoma.
(2011)Receptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression ... -
Reconsidering the causality of TIA1 mutations in ALS
(2018)T-cell-restricted intracellular antigen-1 (TIA1) has been recently reported as a novel amyotrophic lateral sclerosis (ALS) related gene, and has already been adopted in a resource frequently used in ... -
Referral bias in ALS epidemiological studies
(2018)Background: Despite concerns about the representativeness of patients from ALS tertiary centers as compared to the ALS general population, the extent of referral bias in clinical studies remains largely unknown. Using data ... -
Regulating the Regulator: Phosphorylation of PKC θ in T Cells.
(2012)Protein kinase C θ (PKC θ) is a serine/threonine kinase that is now firmly established as a central component in T cell activation, proliferation, differentiation, and apoptosis (Hayashi and Altman, 2007). Since it was ... -
Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
(2013)Suppressor of cytokine signaling (SOCS) proteins are key regulators of CD4+ T cell differentiation, and in particular, we have recently shown that SOCS2 inhibits the development of Th2 cells and allergic immune responses. ... -
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
(2013)Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor κB ... -
Regulation of IL-1?-induced NF-?B by hydroxylases links key hypoxic and inflammatory signaling pathways.
(2013)Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor κB ... -
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
(2010)BACKGROUND: Parasitic helminth infections of humans have been shown to suppress the immune response to allergens. Experimentally, infection of mice with the helminth Schistosoma mansoni prevents allergic airway inflammation ... -
The relationship between syncope, depression and anti-depressant use in older adults
(2014)The authors aim to examine the rates of depression in older patients reporting syncope and the effect of anti–depressants (ADs) on the rates of syncope. This study demonstrates an increased risk of syncope in patients with ... -
Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
(BioMed Central, 2008)Low serum 25 hydroxyvitamin D3 (vitamin D3) is known to perturb cellular function in many tissues, including the endocrine pancreas, which are involved in obesity and type II diabetes mellitus (TIIDM). Vitamin D3 insufficiency ... -
Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.
(2014)Background: Neural tube defects (NTDs), which are among the most common congenital malformations, are influenced by environmental and genetic factors. Low maternal folate is the strongest known contributing factor, making ... -
Replication of a distinct psoriatic arthritis risk variant at the IL23R locus
(2016)Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with the presence of psoriasis. Although the majority of PsA genetic risk loci identified also confer risk for psoriasis, the difference in ... -
Respiratory measures in amyotrophic lateral sclerosis
(2018)Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease that causes skeletal muscle weakness, including muscles involved with respiration. Death often results from respiratory failure within ...
