Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 122-141 of 638
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Dairy intakes in older Irish adults and effects on vitamin micronutrient status: Data from the TUDA study
(2016)Consumption of dairy products has been associated with positive health outcomes including a lower risk of hypertension, improved bone health and a reduction in the risk of type 2 diabetes. The suggested dairy intake for ... -
Data linkage in medical science using the resource description framework: the AVERT model
(2018)There is an ongoing challenge as to how best manage and understand ‘big data’ in precision medicine settings. This paper describes the potential for a Linked Data approach, using a Resource Description Framework (RDF) ... -
Decoy receptors in the regulation of T Helper cell type 2 response
(The Rockefeller University Press, 2003) -
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
(2020)Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but theimportance and regulation of these changes remain unclear. We found that hepcidin, themaster regulator of systemic iron homeostasis, ... -
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
(2015)Poriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared ... -
Deoxycholic acid impairs glycosylation and fucosylation processes in esophageal epithelial cells.
(2012)It is generally accepted that esophageal adenocarcinoma arises from a Barrett's metaplastic lesion. Altered glycoprotein expression has been demonstrated in tissue from patients with Barrett's esophagus and esophageal ... -
Deriving a useful packed cell volume estimate from haemoglobin analysis
(1994)A method is described whereby the packed cell volume (PCV) of a blood sample can be estimated from the haemoglobin concentration. The method defines the relation existing between haemoglobin concentration and the PCV of ... -
Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis
(2020)Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis ... -
Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting.
(2013)The relative contribution of immunological dysregulation and impaired epithelial barrier function to allergic diseases is still a matter of debate. Here we describe a new syndrome featuring severe dermatitis, multiple ... -
Detection of long repeat expansions from PCR-free whole-genome sequence data
(2017)Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) andfragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution ... -
Detection of prospective memory deficits in mild cognitive impairment of suspected Alzheimer's disease etiology using a novel event-based prospective memory task.
(2009)We investigated the relative discriminatory efficacy of an event-based prospective memory (PM) task, in which specificity of the instructions and perceptual salience of the PM cue were manipulated, compared with two widely ... -
Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.
(American Association for Clinical Chemistry, 2007)Background: Impaired vitamin B12 function and decreased vitamin B12 status have been associated with neurological and cognitive impairment. Current assays analyze total vitamin B12 concentration, only a small percentage ... -
Determinants of 25-hydroxyvitamin D in older Irish adults.
(2015)Background: vitamin D deficiency is prevalent in older adults living in Northern Europe and is influenced by several factors which may vary significantly with age. Objective: we aimed to investigate the determinants of ... -
Determining bioavailability of food folates in a controlled intervention study
(2004)Background: The concept of dietary folate equivalents (DFEs) in the United States recognizes the differences in bioavailability between natural food folates and the synthetic vitamin, folic acid. However, many published ... -
Determining the incidence of familiality in ALS: A study of temporal trends in Ireland from 1994 to 2016
(2018)Objective: To assess temporal trends in familial amyotrophic lateral sclerosis (FALS) incidence rates in an Irish population and to determine factors influencing FALS ascertainment. Methods: Population-based data collected ... -
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
(Nature, 2011)Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell motility. Here, we show that ubiquitin-specific protease 17 ... -
Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy.
(2011)BACKGROUND: Meesmann epithelial corneal dystrophy (MECD) is an inherited eye disorder caused by dominant-negative mutations in either keratins K3 or K12, leading to mechanical fragility of the anterior corneal epithelium, ...
