Browsing Clinical Medicine (Scholarly Publications) by Title
Now showing items 43-62 of 638
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Bcl11b is essential for group 2 innate lymphoid cell development
(2015)Group 2 innate lymphoid cells (ILC2s) are often found associated with mucosal surfaces where they contribute to protective immunity, inappropriate allergic responses, and tissue repair. Although we know they develop from ... -
Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1 and MEK
(2005)Chronic myeloid leukemia (CML) is caused by the constitutively active Bcr-Abl tyrosine kinase. This fusion protein is generated by the Philadelphia translocation t(9;22). CML is a progressive condition that invariably ... -
Bcr-Abl regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation is required for proliferation and drug resistance
(2006)The BCR-ABL oncogene is the hallmark of chronic myeloid leukemia, a clonal hematopoietic stem cell disorder. BCR-ABL displays constitutive tyrosine kinase activity, required for its transformation ability. Although the ... -
Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.
(2010)Deoxycholic acid (DCA) is a secondary bile acid that modulates signalling pathways in epithelial cells. DCA has been implicated in pathogenesis of colon carcinoma, particularly by activation of the protein kinase C (PKC) ... -
Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes.
(2011)One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural ... -
Biomarkers of folate status in NHANES: a roundtable summary 1-6
(2011)A roundtable to discuss the measurement of folate status biomarkers in NHANES took place in July 2010. NHANES has measured serum folate since 1974 and red blood cell (RBC) folate since 1978 with the use of several different ... -
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary 1 6
(2011)A roundtable to discuss the measurement of vitamin B-12 (cobalamin) status biomarkers in NHANES took place in July 2010. NHANES stopped measuring vitamin B-12?related biomarkers after 2006. The roundtable reviewed 3 ... -
Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells
(2011)T follicular helper (TFH) cells are critical initiators in the development of T cell-dependent humoral immunity and the generation of protective immunity. We demonstrate that TFH cell accumulation and Ab production are ... -
Breast cancer detection among Irish BRCA1 & BRCA2 mutation carriers: a population-based study
(2015)Aims We investigated the presentation and screening patterns of an Irish cohort of BRCA1/2 mutation carriers with breast cancer. Materials and methods BRCA1/2 mutation carriers with breast cancer were identified in ... -
Btk regulates macrophage polarization in response to lipopolysaccharide.
(2014)Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population. Given the role of Btk as a critical signal transducer ... -
Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council
(Wiley, 2019)The Irish Brain Council is an independent group of organisations which have come together to influence and impact upon brain research in Ireland. The purpose of the Irish Brain Council is to promote ... -
Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection.
(2008)Human macrophages infected with Mycobacterium tuberculosis may undergo apoptosis. Macrophage apoptosis contributes to the innate immune response against M. tuberculosis by containing and limiting the growth of mycobacteria ... -
The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection
(American Society for Microbiology, 2009)The de novo immune response to infectious organisms arises from the innate recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). As the generation of type 2 ... -
C3 glomerulopathy: consensus report.
(2013)C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition. In August 2012, an invited ... -
Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?
(2018)AIM: To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori (H. pylori)-infected patients in Ireland. METHODS: DNA was extracted from antral and corpus biopsies ... -
Cancer risks for BRCA1 and BRCA2 mutation carriers: Results from prospective analysis of EMBRACE
(2013)Background Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for breast cancer, ovarian cancer, ... -
Cancer Symptom Clusters: An Exploratory Analysis of Eight Statistical Techniques
(2014)PURPOSE: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been linked to both cancer incidence and poor prognosis. The frequency of 25(OH)D tests and clinical factors associated with low levels in cancer patients are ...