Browsing Biochemistry (Scholarly Publications) by Author "Lavelle, Edward"
Now showing items 1-20 of 23
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Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines
Lavelle, Edward; Mc Entee, Craig (2019)Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3–4 million cases globally with 100,000–150,000 deaths reported annually. Mostly confined to developing nations, ... -
Autophagy controls IL-1? secretion by targeting pro-IL-1? for degradation
Lavelle, Edward; Creagh, Emma (2011)Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-associated molecules and recently has been shown to influence IL-1? secretion by macrophages. However, the mechanisms behind this are ... -
Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis
Lavelle, Edward; Creagh, Emma; Munoz-Wolf, Natalia (2019)Inflammasomes are multiprotein complexes that respond to infection or injury to activate inflammation. Inflammatory caspases, caspase-1, 4 and 5 in humans, and their murine orthologues caspase-1 and 11 are crucial components ... -
Caspase-11 promotes allergic airway inflammation
Creagh, Emma; Lavelle, Edward; O'Neill, Luke; Mills, Kingston; Zasłona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M.; Carroll, Richard G.; Palsson-McDermott, Eva M.; Hughes, Mark M.; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G.; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J.; Wygrecka, Małgorzata (2020)Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 ... -
Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
Lavelle, Edward; Cox, Donal; Cunningham, Colm; Dunne, Aisling (2019)Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous system cells. IFN‐I has been implicated in neuroinflammation during ... -
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.
Keane, Joseph; O'Sullivan, Mary; O'Neill, Luke; Lavelle, Edward; Corr, Sinead; Palsson Mcdermott, Eva; Sheedy, Frederick; Ni Cheallaigh, Cliona; Gleeson, Laura; Munoz-Wolf, Natalia (2016)Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those ... -
Divergent roles for the IL-1 family in gastrointestinal homeostasis and inflammation
Lavelle, Edward; Finlay, Conor; Mc Entee, Craig (2019)Inflammatory disorders of the gastro-intestinal tract are a major cause of morbidity and significant burden from a health and economic perspective in industrialized countries. While the incidence of such conditions has a ... -
Editorial: Challenges in Vaccinology
Lavelle, Edward (2020)The COVID19 pandemic has focused minds as rarely before on the vital contribution of vaccines to modern life. In addition to issues related to antigen identification, vaccine adjuvants, vectors and formulations, knowledge ... -
Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation
O'Farrelly, Cliona; Mok, Kenneth; Lavelle, Edward; Lynch, Lydia (2014)Obesity is characterized by chronic inflammation associated with neutrophil and M1 macrophage infiltration into white adipose tissue. However, the mechanisms underlying this process remain largely unknown. Based on the ... -
Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease
Lavelle, Edward (2020)Background: The World Health Organization estimates that air pollution is responsible for 7 million deaths per annum, with 7% of these attributable to pneumonia. Many of these fatalities have been linked to exposure to ... -
Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors
Lavelle, Edward; Campbell, Matthew; Hudson, Natalie (2021)It remains unresolved how retinal pigment epithelial cell metabolism is regulated following immune activation to maintain retinal homeostasis and retinal function. We exposed retinal pigment epithelium (RPE) to several ... -
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
Geoghegan, Joan; Rogers, Thomas; Mac Aogáin, Micheál; Mc Loughlin, Rachel; Lavelle, Edward; Foster, Timothy; Fennell, Jerome; Lalor, Stephen (2015)Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using ... -
Mycobacterium tuberculosis Limits Host Glycolysis and IL-1? by Restriction of PFK-M via MicroRNA-21
Sheedy, Frederick; Keane, Joseph; Corr, Sinead; Lavelle, Edward; Johnston, Daniel; Gleeson, Laura; Munoz-Wolf, Natalia (2020)Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we ... -
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses
Lavelle, Edward; Mc Entee, Craig (2019)Helicobacter pylori causes chronic gastric infection that can lead to peptic ulcers and is an identified risk factor for gastric cancer development. Although much effort has been put into the development of a Helicobacter ... -
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
Lavelle, Edward; Moran, Barry; Mc Loughlin, Rachel (2010)Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key role in the initiation and instruction of adaptive ... -
Prevention and treatment of COVID-19 disease by controlled modulation of innate immunity
Lavelle, Edward (2020)The recent outbreak of coronavirus disease 2019 (COVID‐19), triggered by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses an enormous threat to global public health and economies. Human coronaviruses ... -
Targeted nasal vaccination provides antibody-independent protection against staphylococcus aureus
Lavelle, Edward; Mc Loughlin, Rachel (2014)Despite showing promise in preclinical models, anti – Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsoniz- ing antibodies; however, vaccines exclusively ... -
Technological Approaches for Improving Vaccination Compliance and Coverage
Lavelle, Edward (2020)Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical ... -
TLR4, but neither dectin-1 nor dectin-2, participates in the mollusk hemocyanin-induced proinflammatory effects in antigen-presenting cells from mammals
Lavelle, Edward (2019)Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) ...