Targeted nasal vaccination provides antibody-independent protection against staphylococcus aureus
File Type:
PDFItem Type:
Journal ArticleDate:
2014Access:
openAccessCitation:
Misstear, K., Mcneela, E.A., Murphy, A.G., (...), Mcloughlin, R.M., Lavelle, E.C., Targeted nasal vaccination provides antibody-independent protection against staphylococcus aureus, Journal of Infectious Diseases, 209, 9, 2014, 1479-1484Download Item:
Abstract:
Despite showing promise in preclinical models, anti
–
Staphylococcus aureus
vaccines have failed in clinical trials.
To date, approaches have focused on neutralizing/opsoniz-
ing antibodies; however, vaccines exclusively inducing cellu-
lar immunity have not been studied to formally test whether
a cellular-only response can protect against infection. We
demonstrate that nasal vaccination with targeted nanoparti-
cles loaded with
Staphylococcus aureus
antigen protects
against acute systemic
S. aureus
infection in the absence of
any antigen-speci
fi
c antibodies. These
fi
ndings can help
inform future developments in staphylococcal vaccine devel-
opment and studies into the requirements for protective im-
munity against
S. aureus
Sponsor
Grant Number
Science Foundation Ireland (SFI)
12/IA/1421
Author's Homepage:
http://people.tcd.ie/mclougrmhttp://people.tcd.ie/lavellee
Description:
PUBLISHED
Author: Lavelle, Edward; Mc Loughlin, Rachel
Type of material:
Journal ArticleCollections
Series/Report no:
Journal of Infectious Diseases209
9
Availability:
Full text availableKeywords:
Staphylococcus aureusDOI:
http://dx.doi.org/10.1093/infdis/jit636Metadata
Show full item recordLicences: