Browsing Biochemistry (Theses and Dissertations) by Subject "Ph.D. Trinity College Dublin."
Now showing items 1-20 of 56
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A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)All species possess a selection-honed collection of genes whose products function in unison to form a barricade to invading pathogens. The exponential increase in publicly available sequence data has allowed the application ... -
A role for type 111 interferons in the natural killer cell immune response to virus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Natural Killer (NK) cells are fundamental effector cells of the innate immune system that function to eliminate virally infected and transformed cells. One key way in which they do this is through the production of cytokines, ... -
A structural study of ALgE, transporter of alginate from Pseudomonas aeruginosa PAOI
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Pseudomonas aeruginosa is an opportunistic human pathogen that causes serious diseases in humans with immune system deficiencies, such as cystic fibrosis, wound infections, urinary tract infections, and blood stream ... -
A study of the glycosylphosphatidylinositol phospholipase C in Trypanosoma brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Trypanosoma brucei represents a clade of flagellated parasites that cause human and animal trypanosomiases in sub-Saharan Africa. The glycosylphosphatidylinositol phospholipase C (GPI-PLC) is an endogenous enzyme that has ... -
An investigation into the role and regulation of uncoupling protein 1 (UCP 1)
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)The use of the uncoupling protein inhibitor GDP was used to investigate UCP 1 dependent ROS production in BAT and thymus mitochondria. The effect of UCP 1 inhibition by GDP was then corroborated using UCP 1 ablated mice ... -
An investigation into the role of TLR4 interactor with leucine rich repeats (TRIL) in Toll-like receptor responses in brain
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)TLR4 interactor with leucine rich repeats (TRIL) was originally described as a protein required for Toll-like receptor 4 (TLR4) signalling. This thesis provides new insights into the function of TRIL within TLR signalling ... -
An investigation into the role of TMED1 in IL-33/ST2L singalling pathway
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)This thesis set out to characterise the GOLD domain containing protein, TMED1 which had been shown to associate with ST2L, the receptor for the cytokine IL-33 and to investigate its relationship with ST2L. -
An investigation of the link between the bacterial derived queuine molecule and tyrosine production
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Queuine, a dietary derived 7-deazaguanine molecule, has previously been shown to prevent lethality and other symptoms in germ-free mice that were maintained on a tyrosine-free diet. This work suggested a link between queuine ... -
An investigation of the physiological and pathological role of uncoupling proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Uncoupling proteins (UCPs) are found in numerous different tissues and have been associated with many physiological and pathological conditions. After decades of research on uncoupling proteins, there is still only a modest ... -
Biological roles of semicarbazide sensitive amine oxidase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)SSAO is a multifunctional protein that catalyses the oxidative deamination of primary amines, according to the overall reaction RCH2NH2 + O2 + H2O -» RCHO + NH3 + H2O2. In this work, some of the recognised physiological ... -
Cancer cell bioenergetics in response to anti-cancer agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Altered metabolism is a hallmark of cancer (Hanahan and Weinberg, 2011) and while genetic and molecular modifications have enabled cancers to survive the onslaught of various cancer therapies (Pillai et al., 2010), changes ... -
Characterisation of the innate immune response to Campylobacter jejuni colonisation in the chicken intestine
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Campylobacter jejuni is the leading cause of gastroenteritis in humans, and chickens are the primary vector for infection. The microbe colonises the caeca of birds as a commensal, and it is hypothesised that intestinal ... -
Chitosan based adjuvants promote proinflammatory Th1 and Th17 responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Particulate vaccine adjuvants, including alum and biodegradable polymer microparticles, are strong activators of antigen-specific humoral immunity. These particulates enhance NLRP3 inflammasome activation, but they are ... -
Delineating molecular mechanisms of inflammation-induced delirium using a novel mouse model
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Delirium is a syndrome of acute and transient confusion with disruption of attention and cognition; it is a common but underdiagnosed neuropsychiatric condition, which is predictive of increased fimctional decline, dementia ... -
Dendritic cell mediated mucosal cross talk
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Developing efficacious vaccines against enteric diseases is a global challenge and priority. The rational design of such vaccines requires that novel pathways of cellular recruitment to the gastrointestinal (GI) tract be ... -
Development of novel pyrrolo-1,5-benzoxazepines as anti-cancer agents for the treatment of chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Chronic myeloid leukaemia (CML) is characterised by the presence of a constitutively active tyrosine kinase known as Bcr-Abl. The Bcr-Abl kinase inhibitor, STI571, is the first line treatment for CML, but the recent emergence ... -
Distinct local and systemic innate immune gene expression in response to Staphylococcus aureus-induced subclinical mastitis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Both local and systemic innate immune activity has a critical role in maintaining immunological homeostasis in the mammary gland. Dysregulation of the homeostatic process leads to increased infection and related pathology, ... -
Exploring an immune function for murine SARM
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Innate immune cells, such as tissue-residing macrophages and dendritic cells (DCs) play a key role in initiating an immune response following the detection of invading pathogens via germline-encoded pattern-recognition ... -
GlcNAc transferases and glycoengineering in Chinese hamster ovary cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Glycosylation constitutes one of the most important post-translational modifications of proteins, with over 60% of proteins known to be glycosylated. GlcNAc transferases (GnTs) belong to a large subfamily of glycosyltransferases ... -
Identification of the components of the eukaryotic queuine transglycosylase complex and the effect of its substrate queuine on metabolism
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Queuine is a 7-deazaguanine derivative of guanine, which replaces guanine in position 34 of the anticodon loop of the transfer RNA for the amino acids, asparagine, aspartic acid, histidine and tyrosine. This base or related ...