Browsing Biochemistry (Theses and Dissertations) by Subject "Ph.D. Trinity College Dublin"
Now showing items 1-20 of 114
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A biochemical oscillator : experimental and theoretical studies of the peroxidase-oxidase reaction
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The peroxidase-oxidase (PO) reaction is the haem-peroxidase catalysed reaction of molecular oxygen with NADH, and has been shown previously to behave in an oscillatory fashion. It has been used here as a useful laboratory ... -
A role for eIF4A1 in IL-10 induction by LPS
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)microRNAs are a family of short non-coding RNAs that act as fine tuners of gene expression by controlling mRNAs. They have been implicated in numerous diseases including inflammatory diseases. A number of studies have ... -
A role for microRNA-21 in the regulation of gastrointestinal health and disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)The gastrointestinal (GI) tract is a crucial site of innate and adaptive immune regulation, balancing tolerance of beneficial commensal microorganisms and reaction to invading pathgens. Pattern recognition receptors (PRRs), ... -
A study of the effects of neurotoxins on the activity and copper of Ceruloplasmin
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)This thesis focuses on the ability of neurotoxins to affect the activity of the copper transport protein ceruloplasmin (EC 1.16.3.1; ferroxidase) and its intrinsic oxidase activities. The protective properties of taurine ... -
A study of the multiple functions and interactions of semicarbazide sensitive amine oxidase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)This thesis focuses on three of the recognised multiple functions of mammalian semicarbazide sensitive amine oxid ase (SSAO) and the contribution of monoamine oxidase (MAO) to some of these. SSAO is a vascular-adhesion ... -
Activation and function of mucosal gamma delta T cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)γδ T cells are innate-like lymphocytes characterised by rapid activation following infection or tissue injury. They are enriched in the skin and epitheliae of various organs, where breach of the barrier is likely to occur. ... -
Activation of innate immunity by Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)Respiratory infection with Bordetella pertussis is associated with the induction of Th1 cells and these cells, as well as antibody and cells of the innate immune system mediate the clearance of bacteria from the lungs. ... -
An integrated approach to oral vaccination against enteric pathogens
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)While the majority of human pathogens infect the body through mucosal sites, most licenced vaccines are injectable. In fact the only mucosal vaccine that is widely used for infant and childhood vaccination programs is the ... -
An investigation into the expression and physiological function of mitochondrial uncoupling proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)Our study provides evidence that rat thymus contains a functioning mitochondrial uncoupling protein (UCP 1). Using reverse transcriptase-polymerase chain reaction (RT-PCR), we showed that rat thymus contains UCP 1 mRNA. ... -
An investigation into the physiological expression and function of mitochondrial uncoupling protein 1 in thymus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Our study confirms the presence of mitochondrial uncoupling protein 1 in thymus. Using laser scanning confocal microscopy, we showed the constitutive expression of UCP 1 in pure thymocytes. Using a primary peptide antibody ... -
An investigaton of the innate immune response to the vaccine adjuvant chitosan
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Vaccination is widely regarded as one of the most successful medical intervention strategies to have been introduced. Despite its resounding success, significant challenges in the field of vaccine research still remain. ... -
Analysis of mitochondrial proteomes and supercomplex structures in brain tissue
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Mitochondria play a complex multifactorial role in the control of cell bioenergetics. A primary function of mitochondria is the production of adenosine 5'-triphosphate (ATP) by the process of oxidative phosphorylation that ... -
Analysis of the MAPK pathways, in silico and in vitro
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)This thesis takes a combined computational and experimental approach to study the MAPK pathways. These proteins were chosen as they are highly conserved in both sequence and function across all eukaryotes. An evolutionary ... -
Bacterial products as activators of NF-ϰB
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)The ability of bacterial products to potently activate NF-xB has made this transcription factor one of the most widely studied in the immune response. A greater understanding of the mechanisms and signal transduction ... -
Biochemical investigations of hyperhomocysteinemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)Hyperhomocysteinemia, a condition where plasma homocysteine occurs at an abnormally elevated level, is a common finding in vascular disease subjects. Several genetic and nutritional factors have been implicated. The first ... -
Bioenergetics and mitochondrial dynamics in cancer cells and neurons
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Mitochondria in mammalian cells exist as a highly dynamic and interconnected reticulum. This reticular ultrastructure is defined by the opposing forces of fission and fusion, mainly mediated by a group of large GTPases ... -
Characterisation of signalling pathways activated by the IL-1 receptor homologue T1/ST2
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2003)T1/ST2 is a member of the IL-1 receptor family possessing the three characteristic extracellular Ig domains and an intracellular Toll-IL1R (TIR) domain. It is an orphan receptor expressed on a variety of cell types including ... -
Characterisation of T cell responses during Staphylococcus aureus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)The development of anti-S. aureus vaccines has consistently failed in clinical trials, likely due to inefficient induction of cellular immunity. A comprehensive understanding of the discrete T cell subsets critical for ... -
Characterisation of the novel leucine rich repeat containing protein KIAA0644
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)This thesis reports the existence o f a novel leucine rich repeat containing protein annotated as KIAA0644 in the Kazusa DNA Research Institute database (www.Kazusa.or.jp). which was discovered in a study for proteins ... -
Characterisation of the role of Bruton's tyrosine kinase in toll-like receptor signalling
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Toll-like receptors (TLRs) are the primary surveillance system for the detection of pathogens and are crucial to the activation of the host innate response. TLRs contain an extracellular leucine rich repeat region which ...
