Browsing Biochemistry (Theses and Dissertations) by Subject "Immunology"

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  • The activation of unconventional T cells by Staphylococcus aureus 

    Cooper, Andrew (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)
    Staphylococcus aureus is a major human pathogen of multiple tissue sites. The emergence of antibiotic-resistant strains promises greater morbidity in the future. No S. aureus vaccine has so far succeeded in translating ...

  • Analysis of the role of Krebs cycle rewiring in macrophage cytokine production 

    RYAN, DYLAN GERARD (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types rewire metabolic pathways ...

  • Investigating the Impact of the Non-Structural Proteins of Respiratory Syncytial Virus on the Type I Interferon Response 

    Efstathiou, Claudia Mary (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
    Respiratory syncytial virus is the leading cause of bronchiolitis in infants, causing 33.2 million hospital admissions and over 118,000 deaths each year. The primary site of RSV infection are the epithelial cells of the ...

  • Modulation of macrophage responses by the vaccine adjuvant alum 

    GORMAN, AOIFE LOUISE LOUISE (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)
    Recent findings have challenged the classical view of innate versus adaptive immunity, suggesting that innate cells can retain some memory of past immunological insults. This trained immunity which allows for primed cellular ...

  • PKM2 regulation of metabolism but not transcription is important for natural killer cell responses 

    WALLS, JESSICA (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)
    Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating signal transduction and cellular metabolism is essential for effective NK cells responses. The PKM2 isoform of the ...

  • Single cell analysis of iNKT cell heterogeneity, phenotype, and function 

    Kane, Harry (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of ...