Browsing Biochemistry (Theses and Dissertations) by Subject "Biochemistry and Immunology, Ph.D."
Now showing items 1-10 of 10
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A study of the multiple functions and interactions of semicarbazide sensitive amine oxidase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)This thesis focuses on three of the recognised multiple functions of mammalian semicarbazide sensitive amine oxid ase (SSAO) and the contribution of monoamine oxidase (MAO) to some of these. SSAO is a vascular-adhesion ... -
Immunoregulatory mechanisms in the lungs of mice and humans
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The lungs are constantly exposed to inhaled antigen during respiration. The resident immune cells must be hyporesponsive to innocuous inhaled antigen, yet capable of responding appropriately to respiratory pathogens, with ... -
Investigation of the manipulation of phagocytes by Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)The increasing prevalence of antibiotic resistance in Staphylococcus aureus (S. aureus) heralds the advent of a "post-antibiotic era" that urgently necessitates the development of novel treatment methods such as vaccines and ... -
Modulation of innate and adaptive immune responses by adenylate cyclase toxin from Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)CyaA belongs to the repeat-in-toxin (RTX) family of pore-forming toxins that require posttranslational acyiation to lyse eukaryotic cells. While it was known that CyaA binds to a variety of cell types, catalyses the ... -
Nutrient availability regulates Dendritic cell metabolism and function to modulate T cell responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)An emerging view in the field of immunometabolism is that cellular metabolism has a role that extends beyond simply allowing the cell to meet energy and biosynthetic demands, and represents a fundamental physiological ... -
Schistosoma mansoni modulation of allergic responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)It has been proposed that in humans infection with certain parasitic helminths may reduce the propensity to develop allergies in infected populations. Schistosoma mansoni is a parasitic trematode that is implicated as a ... -
Serotonin transporter ligands as anticancer agents : investigations into a mechanism-based therapy for Burkitt's lymphoma and related malignancies
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The recent discovery that some serotonin transporter (SERT) ligands have the potential to act as pro-apoptotic agents in Burkitt’s lymphoma adds greatly to their diverse pharmacological application and is the primary focus ... -
Studies on the three cysteines of mouse glutathione s-transferase P1
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The present study has identified the "alkahne thiol" of mGSTP1 originally described by Phillips and Mantle (1993) as cystein e-169. In addition cysteine-47 is confirmed as the reactive "neutral" pK thiol. Cysteine-14 in ... -
The role of metabolism, hypoxia and immunomodulatory therapy in regulating the human Treg:Th17 cell axis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Th17 cells are important pathogenic effector cells in autoimmune diseases such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). On the other hand, regulatory T (Treg) cells play a crucial role in ... -
The role of T cells in the pathogenesis and prevention of the inflammatory and neurodegenerative changes associated with Alzheimer's disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Alzheimer’s disease (AD) is a neurodegenerative disease, which is characterised by deposition of amyloid-beta (Aβ)-containing plaques and also by neuroinflammatory changes, typified by an increase in proinflammatory cytokine ...