Browsing Physiology (Scholarly Publications) by Date of Publication
Now showing items 21-40 of 136
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Physiological changes following a 12 week gym based stair-climbing, elliptical trainer and treadmill running program in females
(Minerva Medica, 2004)Despite the growing popularity of the elliptical trainer aerobic exercise modality the physiological changes induced following a training program using elliptical trainers remains unknown. Donne investigates the metabolic ... -
Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus
(Wiley & Sons, 2004)Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, ... -
Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus.
(The American Society for Biochemistry and Molecular Biology, 2005)It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory ... -
Effect of body tilt on calf muscle performance and blood flow in humans
(American Physiological Society, 2005)To explore the effect of posture on muscle performance, we tested the effects of body tilt angle on the strength, endurance, and fatigue of, and blood flow into, the plantar flexors. Human subjects were fixed to a tilt ... -
Eye-Hand Coordination: Dextrous Object Manipulation in New Gravity
(ESA Publications Division, 2005) -
The Schizophrenic Faces of PICK1
(2006)Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together ... -
The relationship of medical, demographic and psychosocial factors to direct and indirect health utility instruments in rheumatoid arthritis.
(2006)Cost-effectiveness analysis (CEA) is essential for the comparison of treatments for rheumatoid arthritis (RA). CEA centres on accurate measurement of health utility (HU) preferences. Direct measures of HU in RA patients ... -
The effect of externally generated loading on predictive grip force modulation.
(2007)A characteristic of skilled movement is the ability of the CNS to predict the consequences of motor commands. When we lift an object there is an anticipatory increase in grip force that prevents a grasped object from ... -
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
(2007)The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions ... -
CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.
(Society for Neuroscience, 2007)Deficits in cognitive function are associated with neuroinflammatory changes, typified by activation of glial cells and an alteration of the pro- and anti-inflammatory cytokine balance in the brain. Although there is ... -
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.
(2008)Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1alpha (PGC-1alpha) is a highly regulated transcriptional coactivator that coordinates energy metabolism in mammals. Misregulation of PGC-1alpha has ... -
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
(2008)The current development of immunotherapy for Alzheimer's disease is based on the assumption that human-derived amyloid beta protein (Abeta) can be targeted in a similar manner to animal cell-derived or synthetic Abeta. ... -
Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs
(2008)Long-term potentiation of NMDA-receptor-mediated synaptic transmission (NMDAR-LTP) is a little-understood form of plasticity. In the present study, we investigated whether NMDAR-LTP in the dentate gyrus involves recruitment ... -
Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro.
(2009)Several neurodegenerative disorders are associated with evidence of inflammation, one feature of which is increased activation of microglia, the most likely cellular source of inflammatory cytokines like interleukin-1b. ... -
Bimodal magnetic-fluorescent nanostructures for biomedical applications
(2009)Magnetite-based polyelectrolyte-coated nanostructures were fabricated and the potential for biomedical application assessed in mixed glial cell cultures with nanostructure cellular internalization, cytotoxicty and contribution ... -
Neuroinflammatory changes increase the impact of stressors on neuronal function.
(2009)In the last few years, several research groups have reported that neuroinflammation is one feature common to several neurodegenerative diseases and that similar, although perhaps less profound, neuroinflammatory changes ... -
Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity.
(2009)Background Lipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and ... -
Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration.
(Cambridge University Press, 2009)Evidence suggests that noradrenaline has a tonic anti-inflammatory action in the central nervous system (CNS) via its ability to suppress microglial and astrocytic activation, and inhibit production of inflammatory mediators. ... -
Age-related neuroinflammatory changes negatively impact on neuronal function.
(2010)Neuroinflammatory changes, characterized by an increase in microglial activation and often accompanied by upregulation of inflammatory cytokines like interleukin-1? (IL-1?), are common to many, if not all, neurodegenerative ... -
Effect of body tilt angle on fatigue and EMG activities in lower limbs during cycling
(2010)This study compared the rate of fatigue and lower limb EMG activities during high-intensity constantload cycling in upright and supine postures. Eleven active males performed seven cycling exercise tests: one upright graded ...