The Schizophrenic Faces of PICK1
Citation:
K.K. Dev and J.M. Henley, The Schizophrenic Faces of PICK1, Trends Pharmacol Sci, 27, 2006, 574, 579Download Item:
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Abstract:
Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology.
Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent
findings, together with previously established evidence, highlight the PDZ-domain-containing
protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia
susceptibility gene. Here, we outline possible molecular mechanisms, discuss clinical case-studies
that indicate an unexpected role of PICK1 in schizophrenia and discuss potential avenues for
pharmacological manipulation of PICK1.
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http://people.tcd.ie/devkDescription:
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Author: DEV, KUMLESH
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Trends Pharmacol Sci27
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Full text availableKeywords:
SchizophreniaSubject (TCD):
NeuroscienceDOI:
http://dx.doi.org/10.1016/j.tips.2006.09.007Licences: