Neuroinflammatory changes increase the impact of stressors on neuronal function.
Citation:
Piazza A and Lynch MA, Neuroinflammatory changes increase the impact of stressors on neuronal function., Biochemical Society Transactions, 37, 1, 2009, 303-307Download Item:
Abstract:
In the last few years, several research groups have reported that neuroinflammation is one feature common
to several neurodegenerative diseases and that similar, although perhaps less profound, neuroinflammatory
changes also occur with age. Age is the greatest risk factor in many neurodegenerative diseases, and
the possibility exists that the underlying age-related neuroinflammation may contribute to this increased
risk. Several animal models have been used to examine this possibility, and it is now accepted that,
under experimental conditions in which microglial activation is up-regulated, responses to stressors are
exacerbated. In the present article, these findings are discussed and data are presented from in vitro and
in vivo experiments which reveal that responses to A? (amyloid ?-peptide) are markedly up-regulated in
the presence of LPS (lipopolysaccharide). These, and previous findings, point to a vulnerability associated
with inflammation and suggest that, even though inflammation may not be the primary cause of
neurodegenerative disease, its treatment may decelerate disease progression.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
Author's Homepage:
http://people.tcd.ie/lynchmaDescription:
PUBLISHEDPMID: 19143652
Author: LYNCH, MARINA
Type of material:
Journal ArticleCollections
Series/Report no:
Biochemical Society Transactions37
1
Availability:
Full text availableKeywords:
Neuroscience, aging, amyloid ?-peptide (A?), interleukin-1? (IL-1?)Subject (TCD):
Immunology, Inflammation & Infection , NeuroscienceMetadata
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