Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro.
Citation:
Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, Lynch MA, Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro., Journal of Neurochemistry, 110, 5, 2009, 1547 - 1556Download Item:
Abstract:
Several neurodegenerative disorders are associated with
evidence of inflammation, one feature of which is increased
activation of microglia, the most likely cellular source of
inflammatory cytokines like interleukin-1b. It is now recognized
that interaction of microglia with other cells contributes
to maintenance of microglia in a quiescent state and the
complementary distribution of the chemokine, fractalkine
(CX3CL1) on neurons and its receptor (CX3CR1) on microglia,
suggests that this interaction may play a role in modulating
microglial activation. Here we demonstrate that both
soluble and membrane-bound fractalkine attenuate lipopolysaccharide-
induced microglial activation in vitro. We also
show that fractalkine expression is reduced in the brain of
aged rats and this is accompanied by an age-related increase
in microglial activation. Treatment of aged rats with
fractalkine attenuates the age-related increase in microglial
activation and the evidence indicates that fractalkine-induced
activation of the phosphatidylinositol-3 kinase pathway is required
to maintain microglia in a quiescent state both in vivo
and in vitro.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
Author's Homepage:
http://people.tcd.ie/amlynchhttp://people.tcd.ie/lynchma
Description:
PUBLISHED
Author: LYNCH, AILEEN; LYNCH, MARINA
Type of material:
Journal ArticleCollections
Series/Report no:
Journal of Neurochemistry110
5
Availability:
Full text availableKeywords:
Neuroscience, cytokines, fractalkine expressionSubject (TCD):
Immunology, Inflammation & Infection , NeuroscienceMetadata
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