CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.
Citation:Lyons, A. Downer, E.J. Crotty, S. Nolan, Y.M. Mills, K.H. and Lynch M.A. `CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4? in Journal of Neuroscience, 27, (31), 2007, pp 8309 - 8313
CD200 Ligand?Receptor Interaction Modulates Microglial Activation In Vivo and In Vitro - A Role for IL-4.pdf (published (publisher copy) peer-reviewed) 397.4Kb
Deficits in cognitive function are associated with neuroinflammatory changes, typified by activation of glial cells and an alteration of the pro- and anti-inflammatory cytokine balance in the brain. Although there is evidence to suggest that activation of microglia is regulated by interaction with other cell types in the brain, the mechanism(s) involved is poorly understood. Here, we provide evidence that interaction between CD200 and its receptor plays a role in modulating microglial activation under conditions of chronic and acute inflammation of the brain. We report that interleukin-4 (IL-4) plays a central role in modulating expression of CD200 and identify a mechanism by which IL-4 directly controls microglial cell activation. Our findings provide the first demonstration of a role for IL-4 in modulating CD200 expression and suggest a mechanism for regulation of microglial activation in the intact CNS under inflammatory conditions.
Science Foundation Ireland
Publisher:Society for Neuroscience
Type of material:Journal Article
Series/Report no:Journal of Neuroscience
Availability:Full text available