Overcoming waning immunity in pertussis vaccines: Workshop of the national institute of allergy and infectious diseases
Citation:
Damron FH, Barbier M, Dubey P, Edwards KM, Gu XX, Klein NP, Lu K, Mills KHG, Pasetti MF, Read RC, Rohani P, Sebo P, Harvill ET. Overcoming Waning Immunity in Pertussis Vaccines: Workshop of the National Institute of Allergy and Infectious Diseases, Journal of Immunology, 2020 Aug 15;205(4):877-882Download Item:
Abstract:
Despite high vaccine coverage in many parts of the world, pertussis is resurging in a number of areas in which acellular vaccines are the primary vaccine administered to infants and young children. This is attributed in part to the suboptimal and short-lived immunity elicited by acellular pertussis vaccines and to their inability to prevent nasal colonization and transmission of the etiologic agent Bordetella pertussis In response to this escalating public health concern, the National Institute of Allergy and Infectious Diseases held the workshop "Overcoming Waning Immunity in Pertussis Vaccines" in September 2019 to identify issues and possible solutions for the defects in immunity stimulated by acellular pertussis vaccines. Discussions covered aspects of the current problem, gaps in knowledge and possible paths forward. This review summarizes presentations and discussions of some of the key points that were raised by the workshop.
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Grant Number
SFI
16/IA/4468
Author's Homepage:
http://people.tcd.ie/millsk
Author: Mills, Kingston
Type of material:
Journal ArticleCollections
Series/Report no:
Journal of Immunology;205;
4;
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Full text availableDOI:
http://dx.doi.org/10.4049/jimmunol.2000676Metadata
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