Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism
File Type:
PDFItem Type:
Journal ArticleDate:
2020Access:
openAccessCitation:
Mahon, O.R., Kelly, D.J., McCarthy, G.M. & Dunne, A., Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism, Osteoarthritis and Cartilage, 28, 5, 2020, 603-612Abstract:
A number of studies have demonstrated that molecules called ‘alarmins’ or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprogramming of immune cells, including macrophages, is emerging as a prominent player in determining immune cell phenotype and function. The aim of this study was to investigate if basic calcium phosphate (BCP) crystals which are OA-associated DAMPs, impact on macrophage phenotype and metabolism.
URI:
https://www-sciencedirect-com.elib.tcd.ie/science/article/pii/S1063458419312476?via%3Dihubhttp://hdl.handle.net/2262/93506
Author's Homepage:
http://people.tcd.ie/olmahonhttp://people.tcd.ie/kellyd9
Description:
PUBLISHEDType of material:
Journal ArticleURI:
https://www-sciencedirect-com.elib.tcd.ie/science/article/pii/S1063458419312476?via%3Dihubhttp://hdl.handle.net/2262/93506
Collections
Series/Report no:
Osteoarthritis and Cartilage;28;
5;
Availability:
Full text availableKeywords:
‘alarmins’ or danger-associated molecular patterns (DAMPs), Immunometabolism, Macrophage polarization, BCP crystals, Metabolic reprogrammingDOI:
https://doi-org.elib.tcd.ie/10.1016/j.joca.2019.10.010Metadata
Show full item recordLicences: