Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway.
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Journal ArticleDate:
2017Author:
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2067-04-21Citation:
Raftery N and Stevenson NJ, Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway., Cellular and Molecular Life Sciences, 74, 14, 2017, 2525-2535Abstract:
Interferon-alpha (IFN-a) is a potent anti-viral
cytokine, critical to the host immune response against
viruses. IFN-a is first produced upon viral detection by
pathogen recognition receptors. Following its expression,
IFN-a embarks upon a complex downstream signalling
cascade called the JAK/STAT pathway. This signalling
pathway results in the expression of hundreds of effector
genes known as interferon stimulated genes (ISGs). These
genes are the basis for an elaborate effector mechanism and
ultimately, the clearance of viral infection. ISGs mark an
elegant mechanism of anti-viral host defence that warrants
renewed research focus in our global efforts to treat
existing and emerging viruses. By understanding the
mechanistic role of individual ISGs we anticipate the discovery
of a new ‘‘treasure trove’’ of anti-viral mediators
that may pave the way for more effective, targeted and less
toxic anti-viral therapies. Therefore, with the aim of
highlighting the value of the innate type 1 IFN response in
our battle against viral infection, this review outlines both
historic and recent advances in understanding the IFN-a
JAK/STAT pathway, with a focus on new research discoveries
relating to specific ISGs and their potential role in
curing existing and future emergent viral infections.
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http://people.tcd.ie/stevennjDescription:
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Author: Stevenson, Nigel
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SpringerType of material:
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Cellular and Molecular Life Sciences;74;
14;
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Full text availableKeywords:
Interferon, Interferon stimulated genes (ISGs), JAK/STAT, Anti-viralSubject (TCD):
Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1007/s00018-017-2520-2Metadata
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