The role of folate in the development of colorectal cancer
Citation:
Sharleen Linette O'Reilly, 'The role of folate in the development of colorectal cancer', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004, pp 354Download Item:
Abstract:
Colorectal cancer is a leading cause of morbidity and mortality in Europe and
the USA each year. Most large bowel cancers arise within pre-existing adenomatous
polyps or adenomas. Several case-control and prospective studies have investigated
the relationship between dietary folate intake and the risk of colorectal adenoma
development, which is a well-established precursor of colorectal cancer. This project
focused on establishing a method that would allow two techniques, colonic tissue
folate calculation and the Comet assay, to be combined in a complementary fashion to
investigate the relationship between purported DNA biomarkers, systemic and
localised folate status and their role in the development of colorectal cancer.
Author: O'Reilly, Sharleen Linette
Advisor:
Scott, JohnQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical MedicineNote:
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