Browsing Clinical Medicine (Theses and Dissertations) by Date of Publication
Now showing items 1-20 of 283
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Nutritional aspects of trans unsaturated fatty acids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Dietary trans unsaturated fatty acids from hydrogenated vegetable and fish oils have been shown to raise plasma low density lipoprotein cholesterol and lower high density lipoprotein cholesterol levels at 10%, 6% and 3% ... -
Tools and techniques for improving the assessment of exposure to food chemicals
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Exposure assessments are an integral part of risk assessment and are essential for protecting consumer health and factilitating international trade. The aim of this thesis was to explore the potential usefulness of a number ... -
The nutritional status of hospital patients and healthy elderly living in the community
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Protein-energy undernutrition is known to occur in patients on admission to hospital. In a prospective study of 594 sequential hospital admissions, we assessed the prevalence of undernutrition among patients on admission ... -
Nutritional and metabolic aspects of n-3 polyunsaturated fatty acids in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)The health benefits of fish oils, rich in the n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are multi-faceted, spanning a number of human systems, including the cardiovascular, ... -
Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
Methodological issues in risk assessment of human exposure to artificial sweeteners in food
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The primary aim of this thesis is in estimating food chemical intakes with a specific interest in the area of intense sweeteners. To date all studies of intense sweeteners have been extremely detailed both in the estimate ... -
The study of periodicity of eating & public health nutrition issues
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)This thesis set out to provide an objective understanding of periodicity of eating in a group of free- living adults, by determining the temporal pattern of nutrient intake during eating occasions throughout the day. A ... -
Evaluation of Triple helix-forming Oligonucleotides as modulators of transcriptional initiation in erbB-2/HER-2-positive breast cancer : an anti-tumour approach
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Research over the last several decades has made tremendous strides in the identification of the components of the human genome. Genetic information is expressed by translation of DNA into functional proteins through the ... -
Dietary and genetic factors affecting the cholesteryl ester transfer protein and lipoprotein metabolism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The cholesteryl ester transfer protein (CETP) plays an inherent role in the redistribution of neutral lipids between high density lipoproteins (HDL) and very low density lipoproteins (VLDL) and low density lipoproteins ... -
The folate catabolic process, its implications for folate requirement in humans and its antibacterial drug function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The one-carbon cycle, of which folate is the predominant constituent, is a major carrier of one-carbon units for biochemical synthesis, and is thought to be the sole mechanism of methyl-group transfer. It is involved both ... -
Postprandial lipoprotein metabolism in diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Cardiovascular disease is up to four times greater in patients with Type 2 diabetes compared with nonnoglycaemic individuals (Pyorala et al., 1987; Laakso and Lehto 1997). Abnormalities in lipid metabolism may, in part, ... -
Molecular aspects of human lipid metabolism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The postprandial lipaemic response refers to the changes in lipid and lipoprotein concentrations after consumption of a meal containing more than 15g of long-chain fatty acids. The magnitude and duration of the response ... -
Folic acid fortification of flour : determination of the level that gives rise to unmetabolised folic acid in serum
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)To prevent neural tube defects the Food and Drug Administration (FDA) implemented mandatory folic acid fortification o f all flour milled in the USA at a level 140μg/100g. The Centers for Disease Control (CDC) have proposed ... -
Enternal nutrition in the community setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The practice of tube feeding patients outside the acute hospital setting has existed in Ireland for over a decade. Anecdotal evidence (mainly from hospital dietitians) suggested that the care services for these patients ... -
Dietary fatty acids and diabetes mellitus : effect on postprandial lipoproteins and apolipoproteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2002)This thesis explores the relative merits of dietary polyunsaturated and monounsaturated fat in reducing the postprandial dyslipidaemia which is associated with diabetes. Of particular interest are the apolipoproteins which ... -
Migration of lymphoma and lymphocyte T cells on flat and grooved microfabricated surfaces : comparative analysis of peripheral blood T lymphocytes and lymphoma human T cell line HUT78
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Normal and malignant cell migration represents a fundamentally important process involved in tissue growth and development, inflammation and cancer metastasis. Leukocyte trafficking from blood into tissues is currently ... -
The Tumour Necrosis Factor region in coeliac disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Coeliac disease is a disease of the small intestine, characterised by villous atrophy and crypt hyperplasia. The disease can be defined as an intolerance in genetically susceptible individuals to certain storage proteins ... -
The effects of conjugated linoleic acid on the human immune system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)The cells of the immune system are sensitive to their exogenous environment. Indeed the amount and type of nutrients, including fatty acids, which this environment contains all influence subsequent immune cell functioning. ... -
Transcriptional response to prolonged acid exposure and genetic divergence in Helicobacter pylor
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)Helicobacter pylori infection is strongly associated with gastritis, peptic ulcer and gastric adenocarcinoma. Molecular mechanisms involved in H. pylori adaptation and clinical consequences of infection are unclear. This ... -
Characterisation of the redox protein Thioredoxin from the gastric pathogen Helicobacter pylori
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Gastric colonisation by the Gram-negative bacterium Helicobacter pylori is the primary cause of peptic ulceration, type B chronic gastritis, gastric adenocarcinoma, and is linked to the progression of gastric MALT lymphoma. ...
