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  • Pain sensitivity in general practice 

    Smith, Robert (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 1957)
    This investigation was carried out during the ordinary routine work of general practice. It consisted of applying a simple test and considering the result in relation to the general clinical picture. The test is performed ...
  • A study of congenital malformation in new born in Lagos, Nigeria 

    Lesi, Folorunso Ebun Akinboye (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 1969)
    Summary: Some historical notes of the knowledge and beliefs regarding congenital malformations were reviewed. Based on a survey carried out at the Lagos Island Maternity Hospital, Nigeria, amongst 16,720 consecutive ...
  • Particulate air pollution and mortality in Dublin 1980-1996 

    Goodman, Patrick Gerard (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)
    Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ...
  • The nutritional status of hospital patients and healthy elderly living in the community 

    Corish, Clare Anne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)
    Protein-energy undernutrition is known to occur in patients on admission to hospital. In a prospective study of 594 sequential hospital admissions, we assessed the prevalence of undernutrition among patients on admission ...
  • Nutritional aspects of trans unsaturated fatty acids 

    Cantwell, Mary Margaret (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)
    Dietary trans unsaturated fatty acids from hydrogenated vegetable and fish oils have been shown to raise plasma low density lipoprotein cholesterol and lower high density lipoprotein cholesterol levels at 10%, 6% and 3% ...
  • Enternal nutrition in the community setting 

    McNamara, Edel (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)
    The practice of tube feeding patients outside the acute hospital setting has existed in Ireland for over a decade. Anecdotal evidence (mainly from hospital dietitians) suggested that the care services for these patients ...
  • Methodological issues in risk assessment of human exposure to artificial sweeteners in food 

    Cullen, Muireann Gearóidín (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)
    The primary aim of this thesis is in estimating food chemical intakes with a specific interest in the area of intense sweeteners. To date all studies of intense sweeteners have been extremely detailed both in the estimate ...
  • Molecular aspects of human lipid metabolism 

    Black, Irene Lucy (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)
    The postprandial lipaemic response refers to the changes in lipid and lipoprotein concentrations after consumption of a meal containing more than 15g of long-chain fatty acids. The magnitude and duration of the response ...
  • Evaluation of Triple helix-forming Oligonucleotides as modulators of transcriptional initiation in erbB-2/HER-2-positive breast cancer : an anti-tumour approach 

    Dolan, Colette (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)
    Research over the last several decades has made tremendous strides in the identification of the components of the human genome. Genetic information is expressed by translation of DNA into functional proteins through the ...
  • Dietary fatty acids and diabetes mellitus : effect on postprandial lipoproteins and apolipoproteins 

    Madigan, Claire (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2002)
    This thesis explores the relative merits of dietary polyunsaturated and monounsaturated fat in reducing the postprandial dyslipidaemia which is associated with diabetes. Of particular interest are the apolipoproteins which ...
  • Migration of lymphoma and lymphocyte T cells on flat and grooved microfabricated surfaces : comparative analysis of peripheral blood T lymphocytes and lymphoma human T cell line HUT78 

    Prino-Mello, Adriele (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)
    Normal and malignant cell migration represents a fundamentally important process involved in tissue growth and development, inflammation and cancer metastasis. Leukocyte trafficking from blood into tissues is currently ...
  • Transcriptional response to prolonged acid exposure and genetic divergence in Helicobacter pylor 

    Dong, Quanjiang (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)
    Helicobacter pylori infection is strongly associated with gastritis, peptic ulcer and gastric adenocarcinoma. Molecular mechanisms involved in H. pylori adaptation and clinical consequences of infection are unclear. This ...
  • The Tumour Necrosis Factor region in coeliac disease 

    Daly, Jacqueline S. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)
    Coeliac disease is a disease of the small intestine, characterised by villous atrophy and crypt hyperplasia. The disease can be defined as an intolerance in genetically susceptible individuals to certain storage proteins ...
  • Application of probabilistic modelling to food chemical exposure assessments 

    Gilsenan, Mary B. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)
    Risk assessment of food chemical intake is at the core of food safety policy within the EU and the assessment of food chemical exposure is an integral part of the risk assessment process. There is an increasing demand to ...
  • Characterisation of the redox protein Thioredoxin from the gastric pathogen Helicobacter pylori 

    Fox, Áine T. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)
    Gastric colonisation by the Gram-negative bacterium Helicobacter pylori is the primary cause of peptic ulceration, type B chronic gastritis, gastric adenocarcinoma, and is linked to the progression of gastric MALT lymphoma. ...
  • The role of folate in the development of colorectal cancer 

    O'Reilly, Sharleen Linette (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)
    Colorectal cancer is a leading cause of morbidity and mortality in Europe and the USA each year. Most large bowel cancers arise within pre-existing adenomatous polyps or adenomas. Several case-control and prospective studies ...
  • An extensive evaluation of the validity of reported energy intakes in the North/South Ireland food consumption survey 

    McGowan, Maureen J. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)
    The North/South Ireland Food Consumption Survey (NSIFCS) was conducted between 1997 and 1999, on a representative sample of 1379 adults from the Republic of Ireland and Northern Ireland, aged 18 to 64 years. Food intakes ...
  • Epidemiology of lung cancer in the Republic of Ireland 

    Kabir, Zubair (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)
    The study aimed at investigating the epidemiology of overall lung cancer pattern in the Republic of Ireland across different time-periods. The study also examined the lung cancer incidence pattern across major cell-types ...
  • Cytokine polymorphisms in the study of Helicobacter pylori related gastric pathology 

    Murphy, Gwen (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)
    Persistent local inflammation is now accepted as a risk factor in the development of a number of cancers. Non-cardia gastric cancer is thought to develop after a long lead-time whereby persistent inflammation, caused by ...
  • Effects of bile acids and fatty acids on cell signalling in human colorectal cancer cells 

    Shah, Syed Ahmad (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)
    Colorectal cancer is a multifactorial disease. The interplay between genetic and environmental factors leads to the development of CRC. There have been great advancements in the knowledge of genetic alterations leading to ...