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  • Pain sensitivity in general practice 

    Smith, Robert (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 1957)
    This investigation was carried out during the ordinary routine work of general practice. It consisted of applying a simple test and considering the result in relation to the general clinical picture. The test is performed ...
  • A study of congenital malformation in new born in Lagos, Nigeria 

    Lesi, Folorunso Ebun Akinboye (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 1969)
    Summary: Some historical notes of the knowledge and beliefs regarding congenital malformations were reviewed. Based on a survey carried out at the Lagos Island Maternity Hospital, Nigeria, amongst 16,720 consecutive ...
  • Particulate air pollution and mortality in Dublin 1980-1996 

    Goodman, Patrick Gerard (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)
    Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ...
  • Enternal nutrition in the community setting 

    McNamara, Edel (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)
    The practice of tube feeding patients outside the acute hospital setting has existed in Ireland for over a decade. Anecdotal evidence (mainly from hospital dietitians) suggested that the care services for these patients ...
  • Dietary fatty acids and diabetes mellitus : effect on postprandial lipoproteins and apolipoproteins 

    Madigan, Claire (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2002)
    This thesis explores the relative merits of dietary polyunsaturated and monounsaturated fat in reducing the postprandial dyslipidaemia which is associated with diabetes. Of particular interest are the apolipoproteins which ...
  • Migration of lymphoma and lymphocyte T cells on flat and grooved microfabricated surfaces : comparative analysis of peripheral blood T lymphocytes and lymphoma human T cell line HUT78 

    Prino-Mello, Adriele (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2003)
    Normal and malignant cell migration represents a fundamentally important process involved in tissue growth and development, inflammation and cancer metastasis. Leukocyte trafficking from blood into tissues is currently ...
  • Application of probabilistic modelling to food chemical exposure assessments 

    Gilsenan, Mary B. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)
    Risk assessment of food chemical intake is at the core of food safety policy within the EU and the assessment of food chemical exposure is an integral part of the risk assessment process. There is an increasing demand to ...
  • Epidemiology of lung cancer in the Republic of Ireland 

    Kabir, Zubair (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)
    The study aimed at investigating the epidemiology of overall lung cancer pattern in the Republic of Ireland across different time-periods. The study also examined the lung cancer incidence pattern across major cell-types ...
  • Cytokine polymorphisms in the study of Helicobacter pylori related gastric pathology 

    Murphy, Gwen (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)
    Persistent local inflammation is now accepted as a risk factor in the development of a number of cancers. Non-cardia gastric cancer is thought to develop after a long lead-time whereby persistent inflammation, caused by ...
  • Effects of bile acids and fatty acids on cell signalling in human colorectal cancer cells 

    Shah, Syed Ahmad (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)
    Colorectal cancer is a multifactorial disease. The interplay between genetic and environmental factors leads to the development of CRC. There have been great advancements in the knowledge of genetic alterations leading to ...
  • An investigation of T lymphocyte migration induced by CD44 activation 

    Fanning, Áine (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    This thesis investigates the role of CD44 in signalling active migration in T lymphocytes. A number of murine studies have demonstrated that loss of CD44 expression by T lymphocytes resulted in a delayed migration to sites ...
  • A study of food consumption patterns of children and adults in Ireland : implications for the development of food-based dietary guidelines 

    Burke, Sarah J. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Food-based dietary guidelines (FBDG) are guidelines derived from nutrient targets which are translated into food-based guidelines so they can be adopted by the general population. In order for FBDG to be successful, they ...
  • Conjugated lineolic acid and insulin sensitivity : insights from metabolic and molecular markers 

    Moloney, Fiona (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Insulin resistance signifies an impaired biological response to insulin, and usually implies resistance to the effects of insulin on glucose uptake, metabolism, or storage. This defect is commonly observed in type 2 diabetes ...
  • Effects of polyunsaturated fatty acids on mediators of inflammation associated with atherosclerosis 

    Mullen, Anne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    The inflammatory pathogenesis of atherosclerosis has been defined, largely by the “response to injury” hypothesis. The morphological development of atherosclerosis has also been defined. Monocytes and lymphocytes accumulate ...
  • Development of a tissue-specific prodrug activation approach to prostate cancer gene therapy 

    Foley, Ruth Elizabeth Louise (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Prostate cancer is the most common fatal cancer in Irish men after lung and colorectal cancer. Since the risk of prostate cancer rises with age, its impact is likely to increase as the population ages. Standard treatments ...
  • The transcriptomic analysis of low pH and bile acid induced gene expression in oesophageal cells 

    Duggan, Shane (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Oesophageal adenocarcinoma (OAC) commonly arises from the presence of a premalignant lesion known as Barrett’s Oesophagus (BO). Gastro-oesophageal reflux disease (GORD) has been identified in epidemiological studies as a ...
  • Factors modulating TLR2, TLR4 and HBD2 expression in respiratory epithelium in COPD 

    MacRedmond, Ruth (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    The innate immune response of the respiratory epithelium, employing mechanisms of germ-line encoded, genetically conserved pattern recognition to “non-self’ organisms, is an important component of host defence against ...
  • The immunogenetics of Hepatitis C Virus in a defined unique cohort 

    McKiernan, Susan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Hepatitis C virus is a major cause of liver-related morbidity and mortality worldwide as chronic infection develops in up to 80% of those infected and leads to end-stage liver disease in a significant percentage. The ...
  • Differential gene expression in diabetes : effects on postprandial lipoproteins 

    Lally, Sean (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Diabetes is responsible for a large increase in cardiovascular risk which in many studies has not been reduced by improvement in blood sugar. The postprandial period in diabetes is associated with considerable disturbance ...
  • A novel inflammatory mediator in sinus disease 

    Lang, Emer Elizabeth (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)
    Rhinosinusitis is one of the three most common disorders presenting to primary care physicians, generating high socioeconomic costs (Moss and Parsons 1986; Poole 1999). Understanding the pathomechanisms of inflammation, ...