The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold
Citation:
Louise Ann McMahon, 'The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007, pp 241Download Item:
Abstract:
Adult mesenchymal stem cells (MSCs) offer great potential in tissue
engineering applications as they can be directed to differentiate along
numerous lineages to produce a range of skeletal tissues, including the
chondrogenic lineage. The importance of mechanical loading for the
maintenance of skeletal tissues is well reported. The aim of this thesis was to
demonstrate that the application of cyclic tensile strain to MSC-seeded
collagen-GAG scaffolds regulates the chondrogenic differentiation process, in
the presence of chondrogenic growth factors.
Author: McMahon, Louise Ann
Advisor:
Prendergast., Patrick J.Qualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing EngineeringNote:
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