Show simple item record

dc.contributor.advisorLynch, Marina
dc.contributor.authorVereker, Emily
dc.date.accessioned2018-12-06T13:17:05Z
dc.date.available2018-12-06T13:17:05Z
dc.date.issued2001
dc.identifier.citationEmily Vereker, 'A role for interleukin-1β in synaptic function', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2001, pp 348
dc.identifier.otherTHESIS 6174
dc.identifier.urihttp://hdl.handle.net/2262/85512
dc.description.abstractThe proinflammatory cytokine, interleukin-1β (IL -1β ). one of the most extensively studied cytokines to date, is known to play a pivotal role in neurodegenerative, inflammatory and infectious diseases. Moreover, IL-1β has been implicated in the impairment of long-term potentiation (LTP), a model for learning and memory, and at least one biochemical correlate associated with LTP, i.e., glutamate release. The mechanisms underlying the impairment of LTP in deleterious circumstances, such as in ageing, remains to be fully elucidated. The focus of this study involved investigating the possibility that the stress-activated protein kinases, JNK and p38, underlie this impairment and that activation is initiated by an increase in IL -1β concentration and reactive oxygen species (ROS) formation.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Physiology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12465855
dc.subjectPhysiology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleA role for interleukin-1β in synaptic function
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 348
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie
dc.description.notePrint thesis water damaged as a result of the Berkeley Library Podium flood 25/10/2068


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record