Browsing Genetics by Title
Now showing items 524-543 of 552
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Understanding the diverse roles of polycomb-like proteins in the regulation of chromatin and transcriptional landscapes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The Polycomb repressive complex 2 (PRC2) is a multiprotein chromatin modifying complex that is essential for vertebrate development and frequently deregulated in cancer. In higher eukaryotes, PRC2 is responsible for all ... -
Understanding the molecular interplay between bacterial pathogens and hosts : an evolutionary approach
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The emergence of ecological adaptations is a fundamental conundrum in evolutionary biology. A magnificent and astonishing diversity of life forms occupy a myriad of ecological niches, from stable intra-cellular nutrition-rich ... -
Understanding the role of accessory components in regulation of the Polycomb Repressive Complex 2 in mESCs and cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Polycomb Repressive Complex 2 is a chromatin regulatory complex composed of core subunits EZH1/2, EED, SUZ12 and RBBP4/7, around which several accessory components assemble in a mutually exclusive manner to form structurally ... -
Understanding the role of Polycomb-like proteins in cellular quiescence and cancer
Polycomb proteins are a class of chromatin modifying complexes that are essential regulators of development, differentiation and maintenance of cell lineage. Polycomb proteins exist in two large, distinct, multimeric ... -
The uneasy correspondence between T. H. Huxley and E. P. Wright on fossil vertebrates found in Jarrow, Co. Kilkenny (1865-67)
(2011)The collection of Carboniferous fish and amphibian fossils found in Jarrow in 1864 has been the object of several studies, and has resided successively in at least three Irish museums. This paper draws from the Huxley ... -
Unravelling the evolutionary complexity of RNA viruses
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Viruses are a delicate group of organisms renowned for the serious diseases they inflict. They affect all cellular life and are subdivided into RNA-based and DNA-based viruses depending on the type of genomic nucleotide ... -
Upper Palaeolithic genomes reveal deep roots of modern Eurasians.
(2015)We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus ... -
Usher syndrome type IV: clinically and molecularly confirmed by novel ARSG variants
(2022)Usher syndrome (USH) is an autosomal recessively inherited disease characterized by sensorineural hearing loss (SNHL) and retinitis pigmentosa (RP) with or without vestibular dysfunction. It is highly heterogeneous both ... -
Using an automated ocular vascular analysis software tool to evaluate the role of the inner blood retinal barrier in AMD pathogenesis and examining its application in neurological disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Despite being the most common cause of central retinal blindness globally, there is no treatment for end stage dry age related macular degeneration (AMD). The prevailing school of thought with regard to AMD pathogenesis ... -
Using Micro-Synteny for Phylogenetic Inference and Analysis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Phylogenetics is the study of the evolutionary relationships and history of groups of organisms. Over the past twenty years, the burgeoning number of sequenced genomes has revolutionised the field of phylogenetics taking ... -
Using single molecule Molecular Inversion Probes as a cost-effective, high-throughput sequencing approach to target all genes and loci associated with macular diseases
(2022)Macular degenerations (MDs) are a subgroup of retinal disorders characterized by central vision loss. Knowledge is still lacking on the extent of genetic and nongenetic factors influencing inherited MD (iMD) and age-related ... -
Validation in mesenchymal progenitor cells of a mutation-independent ex vivo approach to gene therapy for osteogenesis imperfecta
(Oxford University Press, 2002)Over 100 dominant-negative mutations within the COL1A1 gene have been identified in osteogenesis imperfecta (OI). In terms of human therapeutics, targeting each of these mutations independently is unlikely to be feasible. ... -
Variance components for bovine tuberculosis infection and multi-breed genome-wide association analysis using imputed whole genome sequence data
(2019)Bovine tuberculosis (bTB) is an infectious disease of cattle generally caused by Mycobacterium bovis, a bacterium that can elicit disease humans. Since the 1950s, the objective of the national bTB eradication program in ... -
Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle
(2014)Open Access Research Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle Ian W Richardson12, Dan G Bradley1, Isabella M Higgins3, Simon J More3, Jennifer McClure4 and Donagh ... -
The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
(2015)PCGF1 encodes one of six human Polycomb RING finger homologs that are linked to transcriptional repression and developmental gene regulation. Individual PCGF proteins define discrete Polycomb Repressor Complex 1 (PRC1) ... -
Versatile Dual Reporter Gene Systems for Investigating Stop Codon Readthrough in Plants
(2009)Background Translation is most often terminated when a ribosome encounters the first in-frame stop codon (UAA, UAG or UGA) in an mRNA. However, many viruses (and some cellular mRNAs) contain ?stop? codons that cause a ... -
Visualizing syntenic relationships among the hemiascomycetes with the Yeast Gene Order Browser
(Oxford University Press, 2006)The Yeast Gene Order Browser (YGOB) is an online tool designed to facilitate the comparative genomic visualization and appraisal of synteny within and between the genomes of seven hemiascomycete yeast species. Three of ... -
What Tyndall read: provenance, contents and significance of the Proby Bequest to Carlow Library
(CARLOW HISTORICAL AND ARCHAEOLOGICAL SOCIETY, 2011-11-30)We give a preliminary description of the provenance and contents of the library that the Tyndalls kept in Hind Head House, in Surrey, and the path it followed to end up in the Carlow County Council Library. For the provenance ...