Browsing Genetics by Title
Now showing items 102-121 of 550
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Dangerous Liaisons: Interplay between SWI/SNF, NuRD and Polycomb in Chromatin Regulation and Cancer.
(2019)Changes in chromatin structure mediated by ATP-dependent nucleosome remodelers and histone modifying enzymes are integral to the process of gene regulation. Here, we review the roles of the SWI/SNF (switch/sucrose ... -
Darwin's Irish correspondence
(Royal Irish Academy, 2008)Searches of Darwin?s correspondence show that some 160 letters crossed between him and naturalists and others with an Irish address. While few in number, compared to Darwin?s 14,000 other known letters, some of this ... -
Data for 3D reconstruction of the corticospinal tract in the wild-type and Semaphorin 6A knockout adult brain
(2019)The corticospinal tract (CST) has a complex and long trajectory throughout the brain. Semaphorin 6A (Sema6A), a member of the semaphorin family, is one of the important regulators of CST axon guidance. Previous studies ... -
Decoding the Genetics of Inherited Retinal Diseases in Ireland
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Title: Decoding the Genetics of Inherited Retinal Diseases in Ireland Short Description: The Target 5000 study aims to provide genetic testing for the estimated 5,000 people in Ireland who are affected by a genetic retinal ... -
Defining the role of the AP2/ERF transcription factors Rap2.4 and Rap2.4b in stress responses in the model plant Arabidopsis thaliana
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2010)This study characterises the molecular properties and the function of two Arahidopsis AP2/ERF transcription factors, Rap2.4 and Rap2.4b. The two genes belong to the DREB subgroup, members of which have been demonstrated ... -
Definition of the cattle killer cell Ig-like receptor gene family: Comparison with aurochs and human counterparts
(2014)Under selection pressure from pathogens, variable NK cell receptors that recognize polymorphic MHC class I evolved convergently in different species of placental mammal. Unexpectedly, diversified killer cell Ig–like receptors ... -
Describing the structural robustness landscape of bacterial small RNAs
(2012)Background: The potential role of RNA molecules as gene expression regulators has led to a new perspective on the intracellular control and genome organization. Because secondary structures are crucial for their regulatory ... -
Detailed analysis of an enriched deep intronic ABCA4 variant in Irish Stargardt disease patients
(2023)Over 15% of probands in a large cohort of more than 1500 inherited retinal degeneration patients present with a clinical diagnosis of Stargardt disease (STGD1), a recessive form of macular dystrophy caused by biallelic ... -
Detection of pleiotropic repeat expansions and their oligogenic contribution to amyotrophic lateral sclerosis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)This thesis aims to advance our understanding of the genetic mechanisms that contribute to amyotrophic lateral sclerosis (ALS). The focus is on investigating pleiotropy in genetic contributors to ALS by examining the ... -
Detection of selection in mammalian genomes and populations
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Genome-wide scans for evidence of positive selection in mammalian genomes have recently become possible with the availability of whole genome sequences. They offer a chance to identify those genes that were of most importance ... -
Development of gene therapies for retinal degenerations
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)The studies described in this thesis explore potential gene therapies for retinal degenerative diseases using adeno-associated virus (AAV) vectors for gene delivery. Inherited retinal degenerations (IRDs) are a leading ... -
Different patterns of gain and loss in genomic evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Evolutionary forces may act on the genome at different levels, from the change of single nucleotides to the duplication or rearrangement of whole chromosomes. Some of these evolutionary processes can be responsible for ... -
Differential apicobasal VEGF signaling at vascular blood-neural barriers
(2014)The vascular endothelium operates in a highly polarized environment, but to date there has been little exploration of apicobasal polarization of its signaling. We show that VEGF-A, histamine, IGFBP3, and LPA trigger unequal ... -
Dissecting the functional link between transcription factor codes and axon guidance genes in Drosophila motor neurons
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)As axons navigate through the extracellular environment they are exposed to different guidance cues that will steer them when sensed by receptors and cell adhesion molecules [CAMS) present on their membranes. The intricate ... -
Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis
(2015)The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, ... -
Dual Origins of Dairy Cattle Farming Evidence from a Comprehensive Survey of European Y-Chromosomal Variation
(PLoS, 2011)Background: Diversity patterns of livestock species are informative to the history of agriculture and indicate uniqueness of breeds as relevant for conservation. So far, most studies on cattle have focused on mitochondrial ...