Investigating the function of Sorting Nexin 8 and chemokines in Niemann Pick Type C disease
Citation:
Gillian Muirhead, 'Investigating the function of Sorting Nexin 8 and chemokines in Niemann Pick Type C disease', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2013, pp 181Download Item:
Abstract:
It was shown that SNX8 (sorting nexin 8), a member of the sorting nexin super-family, plays a role In regulating the SREBP pathway (sterol regulatory element binding protein) of cholesterol homeostasis. Members of the SNX family are involved in intracellular trafficking and sorting of protein cargoes. It is hypothesised that SNX8 plays a role in synaptic transmission and its aberrant function may result in neurodegenerative disorders. To elucidate the role of SNX8 in neuronal function, the expression profile was investigated within the central nervous system using both slice cultures and dissociated primary cultures of neurons and glia.
Author: Muirhead, Gillian
Advisor:
Dev, KumleshQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of PhysiologyNote:
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Full text availableKeywords:
Physiology, Ph.D., Ph.D. Trinity College DublinMetadata
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