Physiology (Theses and Dissertations)
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Investigating the therapeutic utility of Olaparib in Metachromatic Leukodystrophy and Krabbe Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Leukodystrophies encompass a diverse group of genetically-based disorders that impact the development and preservation of myelin in the central nervous system's white matter. These conditions, affecting approximately 1 in ... -
The Impact and Influence of Sports Related Concussion and Cardiovascular Risk Factors on Brain and Heart Health across an Ageing Population
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)This study focused on the relationship between perceptual performance, brain health, and cardiovascular (CV) profiles in both recreational athletes and non-athletes, bridging the gap between sensory integration, cognitive ... -
Identifying the therapeutic potential of novel compounds in the treatment of Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer in adults with a dismal 5-year survival rate of <5%. Despite advanced diagnostic and multimodal treatments including surgery, followed by ... -
Antipsychotics Prevent Psychosine Induced Toxicity in Glial Cells.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glial cells are implicated in the neuropathophysiology of schizophrenia and other neuropsychiatric disorders. Also, the role of altered myelin in the onset and development of schizophrenia and changes in myelin due to ... -
Central and peripheral characterisation of TLR7/8 and endocannabinoid signalling in multiple sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2022)Toll-like receptors (TLRs) are a class of pattern-recognition receptors (PRRs) involved in initiating an immune response to infection or endogenous damage. These receptors are expressed on cells of both the innate and ...