Recent Submissions

  • An investigation of oxidative stress in skeletal muscle 

    Bergin, Patricia (Trinity College (Dublin, Ireland). Department of Physiology, 2005)
    Reactive oxygen species (ROS) are produced as a by-product of oxidative phosphorylation in mitochondria and via various cellular enzyme systems. ROS production is buffered by cellular antioxidant defences, which include ...
  • Beta₂-adrenoceptors as modulators of glial immune function 

    Ryan, Karen M. (Trinity College (Dublin, Ireland). Department of Physiology, 2009)
    The endogenous anti-inflammatory and neurotrophic effects of noradrenahne are mediated by β2-adrenoceptors on astrocytes and microglia in the central nervous system (CNS). Notably, clinical studies demonstrate that ...
  • The effect of ageing and gender on calf vascular conductance and fatigue during plantar flexion excercise 

    Reilly, Heather (Trinity College (Dublin, Ireland). Department of Physiology, 2012)
    Background: Ageing is a complex multifaceted process, which ultimately results in a reduction in neuromuscular function and exercise tolerance. A reduced vasodilatory function and a slower rate of increase in blood flow ...
  • Investigation into possible modulators of microglial activation 

    Murphy, Kevin J (Trinity College (Dublin, Ireland). Department of Physiology, 2010)
    Ageing is associated with an increase in inflammatory changes and a decline in biological function, inflammatory changes in the brain are primarily the result of activated microglia, the immune cells of the brain, and it ...
  • Investigating the function of Sorting Nexin 8 and chemokines in Niemann Pick Type C disease 

    Muirhead, Gillian (Trinity College (Dublin, Ireland). Department of Physiology, 2013)
    It was shown that SNX8 (sorting nexin 8), a member of the sorting nexin super-family, plays a role In regulating the SREBP pathway (sterol regulatory element binding protein) of cholesterol homeostasis. Members of the SNX ...

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