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dc.contributor.advisorDev, Kumlesh
dc.contributor.authorMuirhead, Gillian
dc.date.accessioned2017-02-08T10:26:08Z
dc.date.available2017-02-08T10:26:08Z
dc.date.issued2013
dc.identifier.citationGillian Muirhead, 'Investigating the function of Sorting Nexin 8 and chemokines in Niemann Pick Type C disease', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2013, pp 181
dc.identifier.otherTHESIS 10052
dc.identifier.urihttp://hdl.handle.net/2262/79258
dc.description.abstractIt was shown that SNX8 (sorting nexin 8), a member of the sorting nexin super-family, plays a role In regulating the SREBP pathway (sterol regulatory element binding protein) of cholesterol homeostasis. Members of the SNX family are involved in intracellular trafficking and sorting of protein cargoes. It is hypothesised that SNX8 plays a role in synaptic transmission and its aberrant function may result in neurodegenerative disorders. To elucidate the role of SNX8 in neuronal function, the expression profile was investigated within the central nervous system using both slice cultures and dissociated primary cultures of neurons and glia.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Physiology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15352274
dc.subjectPhysiology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleInvestigating the function of Sorting Nexin 8 and chemokines in Niemann Pick Type C disease
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 181
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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