Construction and development of simliki forest virus vectors for transient gene therapy of model tumours in mice
Citation:
Güniz İskender, 'Construction and development of simliki forest virus vectors for transient gene therapy of model tumours in mice', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2010, pp 250Download Item:
Iskender TCD THESIS 9432 Construction and.pdf (PDF) 164.1Mb
Abstract:
Cancer is a molecular and genetic disease that results from multiple alterations of genes, including proto-oncogenes and tumour-suppressor genes. Virotherapy is a branch of cancer gene therapy where oncolytic viruses are used to treat cancerous cells. Semliki Forest virus (SFV) and its derived vectors (recombinant or replication- competent) have been utilised for the treatment of cancer by exploiting their inherent apoptosis-inducing ability or by expressing high amounts of therapeutic proteins.
Author: İskender, Güniz
Advisor:
Atkins, GregoryQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
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Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinLicences: