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dc.contributor.advisorFeely, John
dc.contributor.authorFitz-Simon, Alexandra Nicola O'Connell
dc.date.accessioned2016-11-29T15:16:45Z
dc.date.available2016-11-29T15:16:45Z
dc.date.issued2006
dc.identifier.citationAlexandra Nicola O'Connell Fitz-Simon, 'Modelling compliance with antihypertensives and statins in Ireland, using a national prescription claims database', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006, pp 396
dc.identifier.otherTHESIS 7947
dc.identifier.urihttp://hdl.handle.net/2262/77981
dc.description.abstractHypertension and high cholesterol, especially in the middle-aged and elderly, are fairly common, and pharmacological therapy is often required to control them. In spite of substantial knowledge of the consequences of uncontrolled blood pressure and high cholesterol (for example cardiovascular and cerebrovascular disease) and the proven benefits of treatment for these conditions, many patients continue to have uncontrolled blood pressure and cholesterol levels. It has been demonstrated in large clinical trials that treatment wth appropriate therapies substantially reduces the risk of morbidity and mortality. While lack of compliance is by no means the only reason for low control rates, many patients prescribed antihypertensives or lipid-lowering therapies do not continue to take them and therefore do not benefit. Previous studies of compliance have often not used the most appropriate methods to analyse drug discontinuations and thus have not been able to explore fully various characteristics of the problem- in particular the patterns of prescription claiming at the individual level, and their longitudinal dependencies. Determining appropriate models for the analysis of discontinuation and switching of statins and antihypertensives in the Irish population may help clinicians making decisions about what and how to prescribe.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12731748
dc.subjectPharmacology and Therapeutics, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleModelling compliance with antihypertensives and statins in Ireland, using a national prescription claims database
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 396
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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