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  • Stress and long-term potentiation 

    Shakesby, Alison (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)
    Stress is a physiological reaction which the body copes with by a variety of mechanisms in order to restore homeostasis. Amongst these is an increase in plasma glucocorticoids, catecholamines and increases in brain ...
  • Regulation of expression of transcription factors nuclear factor-kappa B and early growth response-1 by Helicobacter pylori 

    Abdel-Latif, Mohamed Mahmoud Mohamed (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)
    The Gram-negative bacterium Helicobacter pylori colonizes the human gastric epithelium and is a causative agent of peptic ulcer disease and gastric adenocarcinoma. Although H. pylori colonization is associated with gastric ...
  • Endogenous acetylcholine modulates synaptic plasticity in the hippocampus in vivo 

    Li, Shaomin (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)
    Long-term potentiation (LTP) provides a model for the synaptic mechanisms underlying learning and memory. Acetylcholine (ACh) is an important excitatory transmitter in the hippocampus, and cholinergic activity is essential ...
  • Risk markers for acute stroke in Ireland - association of sodium-lithium countertransport (SLC) with vascular disease 

    Collins, Daniel Ronan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)
    The work in this thesis is divided into two parts, an epidemiological study of the risk markers for stroke in an Irish population and a laboratory study of the possible association between sodium lithium countertransport ...
  • Prescribing for institutionalised older people 

    Flint, Helen Mary (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)
    Introduction: In order to investigate aspects of prescribing practice and drug administration in institutionalised older people, the following aims for the study were developed; -- To compare prescribing practices between ...
  • The use of the General Medical Services prescription database for pharmacoepidemiological studies in Ireland 

    Williams, David (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)
    Pharmacoepidemiology may be divided into three main subdivisions, namely pharmacovigilence, drug utilisation and prescribing quality. An aim of this thesis was to demonstrate the usefulness of the General Medical Services ...
  • A study of antioxidant protection in fluoride induced rat kidney lysosomal damage 

    Arhima, Mahmud H (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)
    Fluoride as an inorganic chemical species is ubiquitous in our environment. Fluorosis is a disease or state of chronic poisoning from long-term exposure to excessive quantities of inorganic compounds of fluorine and is a ...
  • Synaptic plasticity in animal models of stress : serotonergic mechanisms 

    Ryan, Benedict K. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)
    The inhibitory effect of acute elevated platform stress exposure on synaptic plasticity in the CA1 region of the hippocampus in vivo was investigated. Such stress exposure was confirmed to inhibit subsequent long term ...
  • Structural remodelling of the vascular wall in relation to ageing and arterial stiffening 

    McNulty, Marie (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    Structural remodelling of the vascular wall has been investigated in this study in terms of ageing and the process of vascular stiffening. While common structural adaptations are often presumed for ageing and vascular ...
  • Neurotransmitter interactions in the control of spatial memory and exploratory activity in the rat 

    Amico, Francesco (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    The role of the central cholinergic system in learning and memory is well established, with many investigations reporting that central cholinergic hypofunction is correlated with impaired performance on various behavioural ...
  • Modelling compliance with antihypertensives and statins in Ireland, using a national prescription claims database 

    Fitz-Simon, Alexandra Nicola O'Connell (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    Hypertension and high cholesterol, especially in the middle-aged and elderly, are fairly common, and pharmacological therapy is often required to control them. In spite of substantial knowledge of the consequences of ...
  • Pharmaceutical pricing and reimbursement : an Irish perspective 

    Tilson, Lesley H. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)
    There has been a five-fold increase in state expenditure on medicines under the Community Drug Schemes in Ireland over the last decade (1994 to 2004). As a result of this marked increase in pharmaceutical expenditure, the ...
  • Pharmacologically induced long-term enhancement in the hippocampus in vivo 

    Hayes, Jennifer (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2007)
    The present study investigated the mechanisms underlying a pharmacologically induced long-term enhancement (LTE) of fast excitatory synaptic transmission in the CA1 region of the rat hippocampus in vivo. The role of ...
  • A cluster randomised trial of educational interventions to promote rational prescribing in primary care 

    Naughton, Corina (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)
    A randomised controlled trial (RCT) was used to evaluate the effectiveness of individualised GP prescribing feedback delivered as a postal bulletin (PB, n=50 practices) compared to PB plus academic detailing visits (AD, ...
  • Left ventricular diastolic function in early hypertension 

    Almuntaser, Ibrahim Ibrahim (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)
    This thesis presents the development of clinical applications of the relatively new ultrasound modality, TDI in conjunction with the earlier more established modalities of echocardiography. The contents of this thesis ...
  • Genetic polymorphisms and arterial stiffness 

    Zhou, Sixiang (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)
    Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as potential therapeutic ...
  • Health economics in the Irish healthcare setting 

    Walshe, Valerie E. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)
    Economic analysis plays a key role in deciding which healthcare interventions should be made available in collectively funded healthcare systems. The aim of this thesis is to examine the application of health economics in ...
  • Prescription refill models of medication taking behaviour 

    Barron, T. Ian (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2009)
    Medication taking can be defined in terms of two separate and distinct behaviours; adherence and persistence. These behaviours represent the ways in which a patient may take a treatment correctly; namely, acting in accordance ...
  • Assessment of arterial stiffness using oscillometric arteriography 

    Jatoi, Noor Ahmed (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2009)
    The present series of studies examined whether an oscillometric method (Arteriograph), which measures arterial stiffness indices, pulse wave velocity (PWV m/sec), and wave reflection as augmentation index [Alx %], is on ...
  • Pharmacoepidemiology of diabetes mellitus in a national population 

    Zaharan, Nur Lisa (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)
    Diabetes is associated with significant morbidity and mortality from microvascular and macrovascular complications. It is projected that the prevalence of diabetes will increase worldwide especially in the elderly population ...