Browsing Pharmacology & Therapeutics (Theses and Dissertations) by Title
Now showing items 1-20 of 46
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A cluster randomised trial of educational interventions to promote rational prescribing in primary care
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)A randomised controlled trial (RCT) was used to evaluate the effectiveness of individualised GP prescribing feedback delivered as a postal bulletin (PB, n=50 practices) compared to PB plus academic detailing visits (AD, ... -
A study of antioxidant protection in fluoride induced rat kidney lysosomal damage
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)Fluoride as an inorganic chemical species is ubiquitous in our environment. Fluorosis is a disease or state of chronic poisoning from long-term exposure to excessive quantities of inorganic compounds of fluorine and is a ... -
A study of the impact of highly active antiretroviral therapy on the pharmacoepidemiology and pharmacoeconomics of HIV infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)The HIV pandemic has resulted in the most intense and as yet unparalleled effort devoted to antimicrobial drug development ever to be initiated in the developed world. The intensive drug research and development, compressed ... -
Adherence to antihypertensive medication in the United Arab Emirates : patient and doctor perspectives
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)Approximately half of the patients taking medication for hypertension have problems following the prescribed regime to the extent that they do not derive optimal clinical benefit. Prior to this study, there was little data ... -
Antibodies prevent the acute inhibition of long term potentiation by amyloid beta in the rat hippocampus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)The present study investigated the mechanisms underlying the inhibition of long-term potentiation (LTP) of excitatory synaptic transmission by amyloid beta (Aβ) in the anaesthetized rat hippocampus. The role of soluble Aβ ... -
Arterial pulse in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as a potential therapeutic ... -
Assessment of arterial stiffness using oscillometric arteriography
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2009)The present series of studies examined whether an oscillometric method (Arteriograph), which measures arterial stiffness indices, pulse wave velocity (PWV m/sec), and wave reflection as augmentation index [Alx %], is on ... -
Association of PP2A and VE-cadherin in a mono and co-culture with implications on brain microvascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Introduction: Based on the knowledge that VE-cadherin is an integral component of the functioning endothelium in the blood brain barrier. Its transcellular abundance can be altered by post-translational modifications and ... -
Comorbidity and Type 2 Diabetes : prevalence, type and impact on cost and health-related behaviours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2014)Comorbidity is the co-existence of one or more additional conditions in patients with a specified medical condition. It is highly prevalent in patients with diabetes and may be related (concordant) or unrelated (discordant) ... -
Cost Effectiveness of PCSK9 Inhibitors for the Secondary Prevention of Cardiovascular Disease in Ireland: Considerations given to Population Heterogeneity
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2020)The aim of this thesis was to evaluate the cost-effectiveness of PCSK9 inhibitors (alirocumab and evolocumab for the secondary prevention of CVD (cardiovascular disease) in Ireland. Also, to identify the subgroups of this ... -
Cost Effectiveness of Treatment Strategies for Skin Cancer in the Irish Healthcare Setting
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2020)The incidence of both non-melanoma skin cancer (NMSC) and melanoma skin cancer are increasing in Ireland and are associated with significant healthcare costs. Cost-effectiveness analysis (CEA) can assist in resource ... -
Cost-effectiveness of anti-tumour necrosis factor drugs for the treatment of rheumatoid arthritis in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)Rheumatoid Arthritis (RA) is the most common form of inflammatory arthritis. It is a chronic condition that places a substantial burden on patients and their carers, imposing a negative effect on quality of life (QOL), ... -
Endogenous acetylcholine modulates synaptic plasticity in the hippocampus in vivo
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Long-term potentiation (LTP) provides a model for the synaptic mechanisms underlying learning and memory. Acetylcholine (ACh) is an important excitatory transmitter in the hippocampus, and cholinergic activity is essential ... -
Genetic polymorphisms and arterial stiffness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as potential therapeutic ... -
Health economics in the Irish healthcare setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Economic analysis plays a key role in deciding which healthcare interventions should be made available in collectively funded healthcare systems. The aim of this thesis is to examine the application of health economics in ... -
Health technology assessment in the Irish healthcare setting : application to oral anticoagulants
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)The objective of this thesis was to examine the application of economic evaluation within the Irish healthcare setting. In so doing, the author sought to develop skills in indirect comparison, economic modelling, value of ... -
Health Technology Assessment of CD19 CAR T-Cell Therapies in the Irish Healthcare Setting.
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2022)The aim of this research was to undertake health technology assessments of CD19 CAR T-cell therapies, tisagenlecleucel and axicabtagene ciloleucel. A bespoke cost-utility model was developed to examine the cost effectiveness ... -
Hippocampal long-term depression in anaesthetised adult rats: Involvement of glutamate and acetylcholine receptors
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2017)Abstract: Hippocampal long-term depression in anaesthetised adult rats: Involvement of glutamate and acetylcholine receptors Kenneth J. O?Riordan Department of Pharmacology and Therapeutics School of Medicine, University ... -
Identifying early indicators of Emotional and Behavioural Difficulties in Irish children and testing the feasibility of an online parenting intervention for improving child mental health
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Background: Emotional and behavioural difficulties (EBDs) are the most common reason for referral of children and adolescents to mental health services. It is important, therefore, to assess the overall prevalence of EBD ... -
The innate immunomodulatory effects of Aquamin in the context of the metabolic syndrome
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2023)Metabolic disease is a combination of conditions that manifest together, elevating the risk for cardiovascular disease, type 2 diabetes and stroke. Inflammation is a major contributor in the pathophysiology of metabolic ...